补肾养经汤对雌性去势大鼠子宫形态学影响的实验研究

The Effect of BushenyangJing Decoction on the Endometrial of Female Castrate Rats

目的研究补肾养经汤对雌性去势大鼠子宫形态学的影响。方法将60只3月龄大鼠饲养2周后,随机取50只摘除双侧卵巢,余10只行假手术。50只去势大鼠随机分为5组;模型空白组、补肾养经汤高、中、低剂量组、六味地黄丸组,观察各组用药后子宫形态的变化。结果补肾养经汤能够显著增加去势大鼠子宫重量,使去势大鼠子宫内膜明显增厚,并能明显增加子宫内腺体数目及血管分布。结论补肾养经汤可能直接作用子宫,改善子宫内膜的状态,从而缓解子宫萎缩的作用。

Objective To study the effect of BushenyangJing decoction on the endometrial of female castrate rats. Methods 60 female SD rats of 3 months old were fed two weeks. Then 50 rats were selected randomly and removed their ovaries, and 10 rats remained were sham operated. 50 rats were divided randomly into five groups：model group, high dose group of BuShen YangJing decoction,middle dose group of BuShen YangJing decoction, low dose group of BuShenYangJing decoction, and LiuWeiDiHuang Bill group . Every group was carried out corresponding treatment. By removing uterus, histological morphology of each layers of uterus were observed of endometrial. Results BuShenYangJing decoction increased the uterus index. Thickness of endometrial became thicker, and the number of glandules became higher than that of model group. Conclusion BuShenJing decoction can probably act directly on the endometrial ,by regulating the endometrial formation,and delay the atrophy of uterus in ovariectomized rats.