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胰岛β细胞再生与糖尿病治疗的研究进展 被引量：2

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摘要 2005年，美国疾病控制中心（Centers for Disease Control，CDC）公布的资料显示，美国现有糖尿病患者2080万，还有4100万人处于糖尿病前期（pre-diabetes）。中国的糖尿病患者及处于糖尿病前期的人数应该是美国的数倍。外源性补充胰岛素是目前治疗糖尿病的主要措施。然而，外源性胰岛素的使用由于缺乏负反馈调节机制，不能对血糖进行精确调控，
作者 田伯乐 郭志光 郝建强 胡伟明 刘续宝 张肇达
机构地区 四川大学华西医院普通外科 美国明尼苏达大学医学院外科
出处 《胰腺病学》 2007年第3期206-208,共3页 Chinese JOurnal of Pancreatology
关键词 外源性胰岛素 糖尿病治疗 β细胞再生 美国疾病控制中心 糖尿病前期 反馈调节机制 糖尿病患 前治疗
分类号 R587 [医药卫生—内分泌]
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参考文献33

  • 1www.cdc.gov/diabetes
  • 2Shapiro AM,Ladey JR,Ryan EA,et al.Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.N Engl J Med,2000,343:230-238.
  • 3Hering BJ,Kandaswamy R,Ansite JD,et al.Single-donor,marginal-dose islet transplantation in patients with type 1 diabetes.JAMA,2005,293:830-835.
  • 4Meier JJ,Bhushan A,Butler AE,et al.Sustained beta cell apoptosis in patients with long-standing type 1 diabetes:indirect evidence for islet regeneration? Diabetologia,2005,48:2221-2228.
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同被引文献22

  • 1陈秋,夏永鹏,邱宗荫.2型糖尿病大鼠模型的建立与评价[J].天津医药,2006,34(1):33-35. 被引量：37
  • 2陈灏珠,林果为,王吉耀实用内科学[M].14版北京:人民卫生出版社:2013:9.
  • 3Walensky LD. Bcl-2 in the crosshairs:tipping the balance of life and death[J]. Cell Death Differ, 2006,13 (8) : 1339- 1350.
  • 4Skrha J. Pathogenesis of type 1 and type 2 diabetes in 2011 the unifying model of glucoregulation disorder[J]. Vnitr Lek, 2011,57( 11 ) : 949-953.
  • 5Butler AE,Janson J, Bonner -Weir S,et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes[J]. Diabetes, 2003,52( 1 ) : 102-110.
  • 6Farilla L,Hui H, Perfetti R. GLP-1 promoter growth and inhibit apoptosis of beta-cell in Zucker diabetic rat[J]. En- docrinology, 2002,143 4397-4408.
  • 7Butler AE,Jang J,Gurlo T,et al. Diabetes due to a pro- gressive defect in beta-cell mass in rats transgenic for hu- man islet amyloid polypeptide (HIP Rat):a new model for type 2 diabetes[J]. Diabetes,2004,53(6), 1509-1516.
  • 8Brooks C, Dong Z. Regulation of mitochondlial morpholog- ical dynamics during apoptosis by Bcl-2 family proteins:a key in Bak[J]. Cell Cycle, 2007,6(24) : 3043-3047.
  • 9Xie Z, Koyama T, Suzuki J, et al. Coronary reperfusion fol- lowing ischemia:different expression of bcl-2 and bax proteins,and cardiomyocyte apoptosis [J]. Jpn Heart J, 2001,42(6) :759-770.
  • 10Walensky LD. Bcl-2 in the crosshairs:tipping the balance of life and death[J]. Cell Death Differ, 2006,13 (8) : 1339- 1350.

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胰腺病学
2007年 第3期

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