Ki-67和MVD在胃腺癌中的表达及预后意义

Expression and prognostic significance of Ki-67 and microvessel density in gastric adenocarcinoma

目的探讨胃腺癌中增殖抗原Ki-67的表达和微血管密度(MVD)在其预后中的意义。方法应用免疫组化S-P法,检测100例胃腺癌组织中Ki-67表达及MVD值。结果Ki-67表达与胃腺癌浸润深度、淋巴结转移密切相关(P<0．01),与组织学类型无关(P>0．05)。MVD与胃腺癌分期、浸润深度、淋巴结转移及远处转移相关(P<0．05),与分化程度无关(P>0．05)。Ki-67与MVD呈正性相关(P<0．01)。生存期分析显示,高Ki-67阳性表达与高MVD的胃腺癌患者预后差,5年生存率低(P<0．01)。结论胃腺癌中Ki-67表达及MVD值与肿瘤的生长、浸润、转移和预后有密切的关系,联合检测可作为一种胃癌侵袭、转移及分期、判断预后的指标。

Objective To investigate the expression of Ki-67 protein and microvessel density （MVD） in gastric adenocarcinoma and their relations with clinical pathologic features. Methods Ki-67 and MVD in 100 cases of gastric adenocarcinoma were assayed by immunohistochemical staining. Results The Ki-67 was positively correlated with the depth of invasion and lymph node metastasis （P 〈0.01）, but not with the histological types of gastric adenocarcinoma （P 〉0.05）. The MVD was significantly high in tumors with deep penetration, lymph node metastasis and distant metastasis （P 〈0.05）. The recurrence rate after curative resection in hypervascular group was significantly higher than that in hypovascular group （P 〈0.01）, A positive trend of correlation toward significance was found for Ki-67 and MVD （P 〈0.05）, and the prognosis of patients with high Ki-67 and MVD was significantly poorer than that with reduced expression of Ki-67 and low MVD （P 〈0.01）. Conclusions Ki-67 and MVD are positively correlated with growth, invasion, metastasis and prognosis of gastric adenocarcinoma. They can be predictors for the biological behavior and prognosis of tumor.