卡前列甲酯栓并催产素预防产后出血的疗效观察

Effect observation of carboprost with oxytocin on postpartum hemorrhage prevention

目的 观察联合应用卡前列甲酯栓（卡孕栓）和催产素预防产后出血的效果。方法选择240例妊振37～41周。硬膜外麻醉下经阴道分娩的产妇，随机分为联合应用卡孕栓＋催产素组（治疗组）及单纯应用催产素组（对照组），各120例。治疗组产妇在胎儿娩出后即给予催产素20U肌肉注射，后舌下含化卡孕栓1mg。对照组仅在胎儿娩出后单用催产素20U肌肉注射，观察两组产妇失血量，第三产程时间及不良反应。结果两组第三产程时间、产后2h内出血量和产后出血率比较差异显著（P〈0．05）；不良反应比较无显著性差异（P〉0．05）。结论 卡前列甲酯栓配伍催产素可有效预防产后出血，缩短第三产程，且无明显不良反应。

Objective To explore the effect of carboprost compacted with oxytocin on postpartum hemorrhage prevention. Methods Divided transvaginal delivery primipara with peridural anesthesia 240 cases into treatment group （ using carboprost and oxytocin, 120 cases） and control group （only using oxytocin, 120 cases）. Treating group, intramuscular injected oxytocin 20 U as soon as fetal head was expeled, and took sublingualy carboprost 1 mg when foetus was expelled completely;control group, only intramuscular injected oxytocin 20U as soon as fetal head was expeled. Results The level of the third stage time of labor, the hemorrhage of postpartum 2 hours and postpartum hemorrhage rate of treatment group were significantly lower than that in control group（ P 〈0.05 ）. The level of side reaction in study group was not significantly lower than that in control group （ P 〉 0.05 ）. Condusion The c ompatibility of carboprost with oxytocin can prevent postpartum hemorrhage, shorten the third stage of labor and have no evidence of side reaction.