益气养阴法对肺癌患者外周血肿瘤免疫逃逸相关因子的影响

Effect of Therapy of Invigorating Qi and Nourishing Yin on Tumor Immune Escape Related Factors in Peripheral Blood of Patients with Lung Cancer

目的:观察益气养阴法对肺癌免疫逃逸的干预作用。方法:采用前瞻性随机对照研究方法,将60例中晚期非小细胞肺癌气阴两虚型患者随机分为治疗组(n=30)和对照组(n=30),观察治疗前后外周血CD4+CD25+Tr、CD8+CD28+Tc、IL-10、sIL-2R、VEGF、sCD44v6、TGFβ1表达的水平变化,并从肺癌患者瘤体变化、KPS评分、中医证候疗效方面评价肺积方临床疗效。结果:与对照组相比,治疗组外周血CD4+CD25+Tr、VEGF、sCD44v6、TGFβ1、IL-10、sIL-2R水平降低,CD8+CD28+Tc水平升高;在瘤灶的稳定率方面,治疗组优于对照组;治疗组Karnofsky评分改善情况明显优于对照组;治疗组气阴两虚证候改善明显优于对照组。结论:益气养阴法可干预肺癌免疫逃逸,恢复机体的免疫监视作用,提高临床疗效。

Objective： To evaluate the intervention effect of therapy of invigorating qi and nourishing yin on tumor immune escape. Methods： In the perspective randomized control study, sixty cases of advanced none-small cell lung cancer （NSCLC） with deficiency of both qi and yin were randomly divided into two groups： treatment group （n=30） and control group （n=30）.Treatment group was given ＂Feiji Recipe＂ in combination with chemotherapy, and control group received chemotherapy only. The efficacies were assessed by short-term efficacy, Karnofsky performance score, the change of symptoms of traditional Chinese medicine. The change of levels of CD4^＋CD25^＋Tr, IL-10, VEGF, sCD44v6 and TGFβ1 in peripheral blood were observed. Results： In comparison with chemotherapy, therapy of invigorating qi and nourishing yin down-regulated the levels of CD4^＋CD25^＋Tr, VEGF, sCD44v6, TGFβ1, IL-10, improved the short-term efficacy, Karnofsky performance scores and symptoms of traditional Chinese medicine. Conclusions： Therapy of invigorating qi and nourishing yin may intervene in tumor immune escape of patients with NSCLC on multi-pathway.