摘要
目的:观察益气养阴法对肺癌免疫逃逸的干预作用。方法:采用前瞻性随机对照研究方法,将60例中晚期非小细胞肺癌气阴两虚型患者随机分为治疗组(n=30)和对照组(n=30),观察治疗前后外周血CD4+CD25+Tr、CD8+CD28+Tc、IL-10、sIL-2R、VEGF、sCD44v6、TGFβ1表达的水平变化,并从肺癌患者瘤体变化、KPS评分、中医证候疗效方面评价肺积方临床疗效。结果:与对照组相比,治疗组外周血CD4+CD25+Tr、VEGF、sCD44v6、TGFβ1、IL-10、sIL-2R水平降低,CD8+CD28+Tc水平升高;在瘤灶的稳定率方面,治疗组优于对照组;治疗组Karnofsky评分改善情况明显优于对照组;治疗组气阴两虚证候改善明显优于对照组。结论:益气养阴法可干预肺癌免疫逃逸,恢复机体的免疫监视作用,提高临床疗效。
Objective: To evaluate the intervention effect of therapy of invigorating qi and nourishing yin on tumor immune escape. Methods: In the perspective randomized control study, sixty cases of advanced none-small cell lung cancer (NSCLC) with deficiency of both qi and yin were randomly divided into two groups: treatment group (n=30) and control group (n=30).Treatment group was given "Feiji Recipe" in combination with chemotherapy, and control group received chemotherapy only. The efficacies were assessed by short-term efficacy, Karnofsky performance score, the change of symptoms of traditional Chinese medicine. The change of levels of CD4^+CD25^+Tr, IL-10, VEGF, sCD44v6 and TGFβ1 in peripheral blood were observed. Results: In comparison with chemotherapy, therapy of invigorating qi and nourishing yin down-regulated the levels of CD4^+CD25^+Tr, VEGF, sCD44v6, TGFβ1, IL-10, improved the short-term efficacy, Karnofsky performance scores and symptoms of traditional Chinese medicine. Conclusions: Therapy of invigorating qi and nourishing yin may intervene in tumor immune escape of patients with NSCLC on multi-pathway.
出处
《上海中医药大学学报》
CAS
2007年第3期48-51,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
关键词
肺肿瘤
益气养阴法
免疫逃逸
临床研究
None-small cell lung cancer
therapy of invigorating qi and nourishing yin
immune escape
clinical observation