多虑平结合心理疏导治疗肠易激综合征疗效的临床研究

Clinical Efficacy of Doxepin Combined with Psychotherapy on Lrritable Bowel Syndrome

目的:评估多虑平结合心理疏导治疗不同类型肠易激综合征(IBS)患者的临床疗效。方法:80例符合RomeII标准的IBS患者分为四组,A组(便秘型)、B组(腹泻型)、C组(腹泻、便秘交替型)、D组(对照组),A、B、C组给予多虑平及心理疏导,分别观察治疗1周、1月、3月时的疗效。统计治疗前、后4组的Zung's抑郁自评量表(SDS)和焦虑自评量表(SAS)评分。结果:4组SDS、SAS评分均高于正常,A、B、C三组治疗后,SDS、SAS评分显著低于治疗前(P<0.01),D组治疗前后无显著差异(P>0.05)。A组1周、1月、3月的总有效率为:40%、75%、85%,B组为45%、75%、80%,C组为50%、80%、90%,而D组为30%、25%、30%,A、B、C组的总有效率显著高于D组。结论:多虑平结合心理疏导治疗肠易激综合征,能明显提高疗效。

Objective：To evaluate the clinical efficacy of Doxepin combined with psychotherapy on the subgroups of IBS. Methods： Eighty patients with IBS. （Rome Ⅱ criteria ）were divided into Four groups. Group A with constipation predominant and group B with diarrhea predominant and group C with constipation and diarrhea predominant were treated with Doxepin combined with psychotherapy. Group D served as normal control. The efficacy rates were evaluated in 1st week, 1st month, and 3rd month, respectively. The score of Zung＇s self--rating depression scale（SDS） and self--rating anxiety scale（SAS） were evaluated before and after the therapy. Results： The score of SDS and SAS in total patients were higher than normals. The scores of SDS and SAS after therapy in Group A. B, C were significantly higher than those before therapy （P 〈 0. 01）. There was no significant different in Group D（P〉0.05） o The total efficacy rate was 40% in the 1st week,75% in the 1st month, and 85% in the 3rd month in group A; 45%,75%,80%,in group B; 50% ,85% ,90%, In group C; and 30% ,25%.30% in group D, respectively. The total efficacy rate of group A or group B or group C was significantly higher than that of group D （P〈0.01） Conclusion. Doxepin combined with psychotherapy is helpful in the treatment of IBS.