长期服用氯氮平血浆药物浓度的稳定性研究

A study of the stability of plasma clozapine concentration in patents taking clozapine chronically

目的:了解长期服用氯氮平患者的血浆药物浓度的稳定性及其影响因素。方法:对305例稳定使用氯氮平治疗1年以上的精神分裂症住院患者,检测3次氯氮平血浆药物浓度。结果:3次氯氮平血浆药物浓度之间波动:>20.0%者210例,其中>25.0%者127例,>50.0%者50例,>100.0%者7例,有1例波动达到404.2%。在性别、吸烟、联合用药、氯氮平剂量等与氯氮平血浆药物浓度的稳定性有显著关系。结论:长期服用氯氮平的血浆药物浓度的稳定性也可能因性别、吸烟、合并用内科药、氯氮平剂量等的不同而变化。

Objective： To study the stability of plasma clozapine concentration in patients taking clozapine chronically and the related factors. Method：Plasma clozapine concentration was measured three times in 305 inpatients with schizophrenia who had taken clozapine for more than one year. Results：There was a fluctuation in level of plasma clozapine between the three times, that is,210 cases more than 20.0%, among them 127 cases more than 25.0 %, 50 cases more than 50.0 %, 7 cases more than 100.0 %, among them 1 case more than 404.2%. The stability of plasma clozapine concentration was correlated to gander, smoking, combined drugs taking and dosage of clozapine and so forth. Conclusion： Plasma clozapine concentration of those patients who had taken clozapine chronically may change by gander, smoking, combined drugs taking and dosage of clozapine.