米氮平治疗强迫症对照研究

Comparative study of mirtazapine in treatment of obsessive-compulsive disorder

目的:比较米氮平与氟西汀治疗强迫症的疗效和不良反应。方法:分别用米氮平和氟西汀治疗强迫症各27例,疗程8周。应用Yale-Brown强迫症量表(Y-BOCS)、汉密尔顿抑郁量表(HAMD)及汉密尔顿焦虑量表(HAMA)评定疗效。结果:治疗后米氮平组与氟西汀组Y-BOCS、HAMD、HAMA分值均显著下降,两组间疗效差异无显著性。米氮平组不良反应明显少于氟西汀组。结论:米氮平治疗强迫症疗效与氟西汀相仿,不良反应少,可在临床使用。

Objective：To compare the efficacy and side effects of mirtazapine and fluoxetine in the treatment of obsessive-compulsive disorder. Method： Fifty-four patients with obsessive-compulsive disorders were randomly assigned into mirtazapine group（ n = 27） and fluoxetine group （ n = 27）for eight weeks. The efficacy was assessed with Yale-Brown obsessive-compulsive scale （Y-BOCS）, Hamilton depression scale （HAMD） and Hamilton anxiety scale （HAMA）. Results： The scores of Y- BOCS, HAMD, HAMA reduced significantly after treatments in both groups. No significant difference was found in the efficacy between mirtazapine and fluoxetine. The side effects of mirtazapine were less significantly than that of fluoxetine. Conclusion： Mirtazapine is an effective and safe drug in the treatment of obsessive- compulsive disorders.