H-CHOP与E-CHOP方案治疗恶性淋巴瘤的疗效比较

Retrospective comparison between H-CHOP and E-CHOP Protocols for lymphoma

目的比较H-CHOP与E-CHOP方案治疗淋巴瘤的疗效。方法65例淋巴瘤患者31例采用H-CHOP;34例采用E-CHOP方案治疗。应用SSPS11.5计算软件,采用(x2P)Fisher’s Exact Test方法进行统计学处理,分别观察比较两组的疗效、毒副作用。结果H-CHOP方案组:完全缓解率51.61%。总有效率90.32%。E-CHOP方案组:完全缓解率26.47%。总有效率67.65%,统计学分析完全缓解率及总有效率两组差异具有显著性(P<0.05)。多因素分析显示对于初治患者H-CHOP方案的有效率显著高于E-CHOP方案(P<0.05)。两组的主要毒副反应是骨髓抑制:白细胞下降H-CHOP组为77.42%;E-CHOP组为79.41%,统计学上无明显差异;均无发生与毒性有关的死亡。结论H-CHOP方案治疗淋巴瘤,患者具有完全缓解率及有效率高,副反应可耐受的优点,可在临床进一步观察使用。

Objective To compare the therapeutic effect between H-CHOP and E-CHOP protocols for lymphoma. Methods Of 65 patients 31 received H-CHOP and 34received E-CHOP protocol. Results 65 Patients. The complete remission rate and overall response rate were 51.61% and 90.32% in H-CHOP group, and they were 26.47% and 67.65%. in E-CHOP group. There was a significant different （p〈0.05） in the complete remis- sion rate and overall response rate between the two groups. The main toxicity was myelosuppression. The leukocytopenia rate was 77,42% in H-CHOP group and 79.41% in E-CHOP group （p〉0.05）. No fatal toxicity was encountered in the groups. Conclusions The results of this study demonstrate that H-CHOP may be an effective protocol, So this protocol can be considered as a routine and salvage protocol for lymphoma.