喹喔啉酮类化合物的研究进展

Advances in the research of quinoxalinone derivatives

喹喔啉酮类(或喹喔啉-2-酮)化合物是一类具有重要应用价值的杂环化合物,具有多种生物活性,可作为抗肿瘤剂、HIV-1逆转录酶抑制剂、N-甲基-D-天(门)冬氨酸受体拮抗剂、抗(真)菌剂、抗凝血剂、降血糖剂等。该文从化合物生物活性的角度对喹喔啉酮类化合物在不同领域中的应用及研究进展进行综述。

Heterocyclic quinoxalinone（or quinoxalin-2-one） derivatives have been proven to exhibit a wide range of significant biological properties including acting as anticancer agents, NMDA receptor antagonists, antimicrobial（or antifungal） agents, antithrombotic agents, and glycogen phosphorylase inhibitors, etc. Recently, the deeply research of quinoxalinone skeleton led to the quickly development of its utility and applications, which are reviewed briefly.