不同剂量运脾方对脾虚大鼠小肠功能的影响

Effect of Yun-Pi Prescription in Different Dosage on Small Intestinal Function of Splenic Asthenia Rats

目的观察治疗儿童厌食症的有效方药运脾方不同剂量对脾虚大鼠小肠功能的影响,探索运脾方临床治疗效果的作用机理。方法建立利血平致脾虚动物模型,设立正常组、模型组、阳性对照组(消食健儿糖浆组)、运脾方大剂量组、运脾方中剂量组、运脾方小剂量组,测定大鼠体重变化及食量消耗,观察大鼠尿D-木糖排泄率。结果运脾方能明显增加脾虚大鼠的食量和体重,增加D-木糖的排泄率。结论运脾方能够改善脾虚大鼠小肠吸收功能,并呈量效关系。

Objective To observe the effect of Yun-Pi Prescription in different dose on small intestinal function of splenic asthenia rats, so as to explore mechanisms of Yun-pi Prescription in treatment of children apositia. Methods Experimental rats were randomly divided in to six groups： the control group, the model group, the positive control group （Xiao shi Jian er Syrup group）, Yun-Pi Prescription in high, middle and low dose group. Measure the changes of body weight and food intake, observe excretory rate of D-xylose of rats. Results Yun-Pi Prescription could ＇increase body weight and food intake, improve excretory rate of D-xylose in splenic asthenia rats. Conclusion Yun-Pi Prescription could improve the small intestinal absorptive function of splenic asthenia rats with dose-effect relationship.