乳腺癌中p27表达的临床意义及其与C-erbB-2、p53的关系

Clinical significance of p27 expression in breast carcinoma and its correlation with C-erbB-2 and p53

目的研究p27在乳腺癌中表达的临床意义及与C-erbB-2、p53的关系。方法应用免疫组化SP法对50例乳腺癌组织p27、C-erbB-2及p53的表达、30例乳腺良性病变组织p27的表达进行检测。结果p27蛋白在乳腺癌组织和乳腺良性病变组织表达率分别为54%和73.33%。p27蛋白在乳腺癌组织中表达与其在乳腺良性病变组织中表达相比有显著性差异(P<0.05),p27蛋白在乳腺癌组织中表达与腋淋巴结有无转移、临床分期及C-erbB-2、p53的表达成负相关(P<0.05),与ER的表达成正相关(P<0.05),而与年龄、肿瘤大小、孕激素受体(PR)的表达无相关性(P>0.05)。结论p27可能与乳腺癌发生、发展及腋淋巴结转移有关,p27与C-erbB-2、p53蛋白的表达成负相关。p27蛋白的表达对判断乳腺癌临床进展及预后有一定的参考价值。

Objective To investigate the expression and clinical significance of p27 in breast carcinoma and its correlation with C-erbB-2 and p53. Methods The expression of p27 and C-erbB-2 was determined by SP irnrnunohistochemical technique in 50 cases of breast carcinoma and 30 cases of benign breast tissue. Results Positive expression rate of p27 was 54% in breast carcinoma and 73.33% in benign breast tissue（P〈0. 05）. The negative correlation existed between the expression of p27 and the lymph node metastasis, clinical stages, the expression of C-erbB-2 and p53. The positive correlation existed between the expression of p27 and ER. The correlation did not exist between the expression of p27 and age, sizes of tumor, the expression of PR （P 〉 0. 05）. Conclusion The expression of p27 probably is associated with the development of breast carcinoma and lymph node metastasis. The expression of p27 is negatively correlated with the expression of C-erbB-2 and p53. The expression of p27 can be used in predicting the clinical progression and prognosis of breast carcinoma.