超敏C-反应蛋白与脑血管疾病危险因素的相关性研究

Clinical study on the correlation between high sensitivity C - reactive protein and risk factors in cerebral vessal disease

目的探讨超敏C-反应蛋白（hs-CRP）对急性脑卒中发生的影响及与脑血管疾病危险因素的关系。方法采用散射免疫比浊法检测118例急性脑卒中患者（急性脑卒中组,其中脑梗死86例,脑出血32例）和67例正常健康人（正常对照组）的hs-CRP水平,分析hs-CRP与脑血管疾病危险因素之间的关系。结果与正常对照组比较,急性脑卒中组hs-CRP水平显著升高（P〈0.01）,脑梗死组与脑出血组间比较差异无显著性。Pearson相关分析结果显示,hs-CRP值与脑血管疾病危险因素（年龄、体质指数、腹围、收缩压、舒张压、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇）均呈显著相关（P〈0.05或P〈0.01）;多因素逐步回归分析结果显示,hs-CRP值与收缩压、空腹血糖、甘油三酯、总胆固醇呈显著正相关（P均〈0.01）。结论hs-CRP与急性脑卒中患病显著相关;血压、空腹血糖与血脂是影响hs-CRP的主要独立因素。

Objective To investigate correlation between high sensitivity C- reactive protein （hs -CRP） and risk factors of acute stroke and cerebrovascular disease. Methods Hs - CRP levels were determined in 118 hypertensive patients with acute stroke （86 patients with cerebral infarction and 32 patients with cerebral hemorrhage） and in 67 healthy volunteers as normal control group by scattered radiation immunoturbidimetry. The difference in hs -CRP was analyzed in these two groups, and the correlation between hs - CRP and the cerebrovascular disease risk factors were analyzed. Results Acute stroke patients had a significantly higher level of hs -CRP compared with healthy subjects （P 〈 0.01）. There was no significant difference of hs -CRP level between cerebral infarction group and cerebral hemorrhage group. Hs -CRP level was significantly correlated with cerebrovascular accident risks such as age, body mass index （BMI）, abdominal circumference, systolic and diastolic pressure, serum total cholesterol, triglycerides, low - density lipoprotein cholesterol （LDL - C）, high - density lipoprotein cholesterol （HDL - C） and serum fasting blood glucose by Pearson correlation analysis （P〈0.05 or P〈0.01）, and strong positive correlations were observed between the hs -CRP level and systolic pressure, the serum fasting blood glucose, total cholesterol, triglycerides, LDL -C and HDL -C by analysis using the multivariate stepwise regression model （all P〈 0.01）. Conclusion The high level hs -CRP is in close relation with acute stroke, and blood pressure, serum fasting blood glucose and cholesterol are significant and independent risk factors that might influence the level of hs -CRP.