摘要
目的观察分析外周血淋巴细胞亚群及细胞因子的变化在Graves病(GD)发生发展中的临床意义。方法分别检测GDa组(初诊)、GDb组(治疗后)、GDc组(复发)和正常组外周血中淋巴细胞亚群、IL-12、IL-10的表达。结果与对照组相比,GDa组和GDc组CD8+、CD3+及CD1+6淋巴细胞显著下降(P<0.01),CD4+/CD8+比值和CD1+9明显升高(P<0.01);GDa组的IL-10、IL-12均高于对照组(P<0.05);GDb组的IL-12和IL-12/IL-10较GDa组显著降低(P<0.05);GDa和GDc组的CD1+6与CD8+呈明显正相关(P<0.05),与CD1+9呈明显负相关(P<0.01)。结论GD患者淋巴细胞亚群的分布特征和Th1/Th2的平衡紊乱在GD的发生发展过程中有着重要临床意义。
objective To explore the clinical role of the changes of peripheral blood lymphocyte subsets and eytokines in Graves' disease. Methods The percentage of T lymphocyte subsets, serum IL-12 ,IL-10 and thyroid hormone were determined in GDa group (untreated), GDb group (after treated), GDe group (relapsed) and 20 control eases. Results CD^+8 ,CD^+3 and CD^+16 were decreased significantly (P〈0.01), the ratio of CD^+4/CD^+8 and CD^+19 were increased (P〈0.01) in GDa group and GDe group compared with the control group, the above indexes turned to normal scope in the GDb group; In GDa group,both IL-12 predueed by Thl cells and IL-10 from Th2 cells increased compared with control group (P〈0.05, P〈0.01), IL-12/IL-10 ratio also increased (P〈 0.05) ; In GDb group, IL-12 and IL-12/IL- 10 decreased significantly compared with GDa group (P〈0.05) ; FT4 has an obviously correlation with CD^+8,CD^+19,CD^+16 T lymphocyte in GDa group(P〈0.05);CD^+16 has a positive correlation with CD^+8 (P〈0.05) ,negative correlation with CD^+19 (P〈0.01) in GDa and GDe group. IL-12 has positive correlation with FT3 and FT4 (P〈0.05), negative correlation with CD16 ( P=0.0357 ). Conclusion The lymphocyte subsets distribution and Thl/Th2 eytokine imbalance play a key role in the pathogenesis, development of GD patients.
出处
《临床内科杂志》
CAS
2007年第6期379-381,共3页
Journal of Clinical Internal Medicine