期刊文献+

淋巴细胞亚群和细胞因子在Graves病患者外周血中的漂移特征

The drift of peripheral blood lymphocyte subsets and expression of serum cytokines in graves disease
下载PDF
导出
摘要 目的观察分析外周血淋巴细胞亚群及细胞因子的变化在Graves病(GD)发生发展中的临床意义。方法分别检测GDa组(初诊)、GDb组(治疗后)、GDc组(复发)和正常组外周血中淋巴细胞亚群、IL-12、IL-10的表达。结果与对照组相比,GDa组和GDc组CD8+、CD3+及CD1+6淋巴细胞显著下降(P<0.01),CD4+/CD8+比值和CD1+9明显升高(P<0.01);GDa组的IL-10、IL-12均高于对照组(P<0.05);GDb组的IL-12和IL-12/IL-10较GDa组显著降低(P<0.05);GDa和GDc组的CD1+6与CD8+呈明显正相关(P<0.05),与CD1+9呈明显负相关(P<0.01)。结论GD患者淋巴细胞亚群的分布特征和Th1/Th2的平衡紊乱在GD的发生发展过程中有着重要临床意义。 objective To explore the clinical role of the changes of peripheral blood lymphocyte subsets and eytokines in Graves' disease. Methods The percentage of T lymphocyte subsets, serum IL-12 ,IL-10 and thyroid hormone were determined in GDa group (untreated), GDb group (after treated), GDe group (relapsed) and 20 control eases. Results CD^+8 ,CD^+3 and CD^+16 were decreased significantly (P〈0.01), the ratio of CD^+4/CD^+8 and CD^+19 were increased (P〈0.01) in GDa group and GDe group compared with the control group, the above indexes turned to normal scope in the GDb group; In GDa group,both IL-12 predueed by Thl cells and IL-10 from Th2 cells increased compared with control group (P〈0.05, P〈0.01), IL-12/IL-10 ratio also increased (P〈 0.05) ; In GDb group, IL-12 and IL-12/IL- 10 decreased significantly compared with GDa group (P〈0.05) ; FT4 has an obviously correlation with CD^+8,CD^+19,CD^+16 T lymphocyte in GDa group(P〈0.05);CD^+16 has a positive correlation with CD^+8 (P〈0.05) ,negative correlation with CD^+19 (P〈0.01) in GDa and GDe group. IL-12 has positive correlation with FT3 and FT4 (P〈0.05), negative correlation with CD16 ( P=0.0357 ). Conclusion The lymphocyte subsets distribution and Thl/Th2 eytokine imbalance play a key role in the pathogenesis, development of GD patients.
作者 齐翠娟 袁莉
出处 《临床内科杂志》 CAS 2007年第6期379-381,共3页 Journal of Clinical Internal Medicine
关键词 淋巴细胞亚群 NK细胞 白细胞介素-10 白细胞介素-12 Lymphocyte subsets NK cell Intedeukin-10 Interleukin-12
  • 相关文献

参考文献13

  • 1Misaki T,Konishi J,Iida Y,et al.Altered balance of immunoregulatory T lymphocyte subsets in autoimmune thyroid diseases.Acta Endoc,1984,105:200-204.
  • 2Ishikawa N,Eguchi K,Otsubo T,et al.Reduction in the supressor-inducer T cell subset and increase in the helper T cell subset in thyroid tissue from patients with Graves ' disease.J Clin Endocrinol Metab,1987,65:17-23.
  • 3Nakazato N,Yoshida K,Mori K,et al.Antithyroid drugs inhibit radioiodine · induce increases in thyroid autoantibodies in hyperthyroid Graves 'disease.Thyroid,1999,9:775-779.
  • 4Allen E M,Bartlett S T.The effect of methimazole,iodine and splenocytes on thyroid transplants in BB/Wor rats.Transplantation,1999,18:25-30.
  • 5Volpe R.The immunomodulatory effects of antithyroid drugs are mediated via actions on thyroid cells,afecting thyrocyteimmunocyte signalling:A review.Curr Pharm Des,2001,7:451-456.
  • 6Bossowski A,Urban M,Stasiak-Barmuta A.Analysis of changes in the percentage of B (CD19) and T (CD3) lymphocyte,subsets CD4,CDsand their memory (CD45RO),and na? ye (CD45RA) T cells in children with immune and non-immune thyroid diseases.J Pediatr Endocrinol Metab,2003,16:63-70.
  • 7Bossowski A,Urban M,Stasiak-Barmuta A,et al.Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell population in children and adolescents with Graves' disease.Pediatr Res,2003,54:425-429.
  • 8Solerte SB,Precerutti S,Gazzaruso C,et al.Defect of a subpopulation of natural killer immune cellsin Graves'disease and Hashimoto's thyroiditis:normalizing effect of dehydroepiandrosterone sulfate.Eur J Endocrinol,2005,152:703-712.
  • 9杨莉萍.白细胞介素-12的免疫调节作用及临床应用[J].中国新药杂志,2003,12(12):991-995. 被引量:4
  • 10Phenekos C,Vryonidou A,Gritzapis AD,et al.Thl and Th2 serum cytokine profiles characterize patients with Hashimoto's thyroiditis (Th1)and Graves ' disease (Th2).Neuroimmunomodulation,2004,11:209-203.

共引文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部