口腔地米溃疡糊剂中地塞米松质量浓度的测定

Determination of the Content of Dexamethasone Acetate in Stomatology Ulcer Pasta

目的为口腔地米溃疡糊剂的质量标准提供质量浓度测定的依据。方法采用异烟肼比色测定口腔地米溃疡糊剂中地塞米松的质量浓度。结果地塞米松的质量浓度为6～16μg/mL时,吸收度与地塞米松对照品质量浓度线性关系良好。地塞米松平均回收率为98.9%,地塞米松质量浓度相对标准偏差小于1%(n=5)。结论异烟肼比色测定地塞米松质量浓度简便易行、准确可靠。

Objective To provide content-measuring evidences for establishing the quality criteria of dexamethasone acetate ulcer pasta. Methods Content of dexamethasone acetate was assayed by the isonicotinyl hydrazine （INH） colorimetry. Results The good linear range was 6-16 μg/mL （r=0.999 1）. The average recovery of dexamethasone acetate was 98.9%, and relative standard deviation was low than 1%（n=5）. Conclusion It is easy, convenient, accurate and dependable for INH colorimetry to determine the content of dexamethasone acetate.