摘要
目的研究前伸下颌后明胶酶(MMP-2、MMP-9)在大鼠髁突软骨内表达的变化。方法选取5周龄雄性SD大鼠60只,随机等量分成实验组和对照组,实验组大鼠白天配戴自制的上颌斜面导板式活动矫治器引导下颌前伸,对照组大鼠不戴矫治器。在实验的1、2、4周处死动物,免疫组化检测明胶酶在大鼠髁突软骨内表达的变化。结果在正常髁突软骨内,MMP-2呈中等强度表达,MMP-9表达很低。前伸下颌后,髁突软骨内MMP-2的表达无明显变化,而MMP-9的表达显著增高(P<0.01)。结论明胶酶参与了功能矫形时下颌髁突软骨的适应性改建。
Objective To investigate the changes in expression of gelatinase（MMP-2, MMP-9） in young rat condylar cartilage during functional mandibular advancement. Methods Sixty male 5-week old SD rats were divided into experimental and control groups. The mimic functional appliances were used in experimental group rats. The animals were sacrificed after 1, 2, 4 weeks. The immunoreactivity of gelatinase was detected by immunohistochemistry. Results In normal mandibular condylar cartilage, the immunoreactivity of MMP-2 was rather strong, the tivity of MMP-9 was very weak. Following functional mandibular advancement, the expression of MMP-9 was significandy increased（P〈0.01）, but immunoreactivity of MMP-2 had no significant changes. Conclusion Gelatinase plays an important role in the adaptive remondling of young rat condylar cartilage during functional mandibular advancement.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2007年第3期299-301,305,共4页
West China Journal of Stomatology
基金
四川省科技攻关资助项目(2006Z08-005-11)
口腔生物医学工程教育部重点实验室开放课题资助项目(2006年)
关键词
髁突软骨
功能矫形
明胶酶
mandibular conlylar cartilage
orthopedics
gelatinase
