摘要
应用P糖蛋白(Pgp)单抗UIC2及流式细胞术间接免疫荧光法检测75例初治成人急性髓细胞白血病(AML)Pgp表达,并探讨其临床意义。结果23例(30.7%)表达Pgp,19例(82.6%)Pgp+AML共表达CD34.Pgp表达与初诊性别、年龄、肝脾肿大、外周血象等无明显相关性.M3中未见Pgp表达。伴t(8;21)及t(15;17)染色体异常的AMLPgp表达低。Pgp+及Pgp-AML之完全缓解率分别为26.1%及76.9%(P<0.05).CD34+与CD34-AML的CR率分别为42.9%及84.8%(P<0.05),Pgp+/CD34+与Pgp-/CD34-AML的CR率分别为15.8%及86.2%(P<0.05)。结果表明Pgp及CD34是成人AML预后差的重要原因。
The P-glycoprotein(Pgp) in 75 Patients suffering from untreated adult acute myeloid leukemia(AML) previously was assayed by monoclonal antibody U1C2 with FCM. The Pgp was positive(≥10% ) in 30. 7% of cases and coexpressed with CD34 antigen in the most cases of Pgp+AML. There was no relationship between Pgp expression and sex, age,heptospienomegaly,peripheral bloodgarms or FAB subsets except for M3 subtype which had no Pgp expression. The complete remission(CR) rate of Pgp+AML(26. 1 % ) was significantly lower than that of Pgp-AML(76. 9%). Furthermore,CR rate of Pgp+/CD34+AML and Pgp-/CD34-AML was 15. 8% and 86. 2% respectively. These suggest that Pgp is an index of poor prognosis for patients suffering from untreated adult AML previously.
出处
《苏州医学院学报》
1997年第1期4-6,197,共3页
Acta Academiae Medicinae Suzhou
基金
江苏省科委资助
关键词
髓细胞性
急性白血病
P糖蛋白
流式细胞术
预后
Leukemia
myclocytic
acute multidrug resistance
monoclonal antibody
flow cytometry