摘要
幽门螺杆菌自1983年Warren和Marshall发现后一直备受关注,现已确定,幽门螺杆菌(Hp)与胃炎、消化性溃疡、胃腺癌和黏膜相关性淋巴样组织淋巴瘤有关。幽门螺杆菌胃部感染,可直接或间接产生自由基,引起胃黏膜上皮细胞损伤、坏死形成溃疡,另外,自由基导致胃黏膜细胞增生、凋亡失衡,对生物大分子如脂质、蛋白质及DNA造成伤害,从而诱发胃癌。
Helicobacter pylori（Hp） found by Warren and Marshall in 1983 is a Gram-negative bacterium identified as the aetiological agent of peptic ulcer disease, gastric adenocarcinoma and B-cell mucosal-associated lymphoid tissue （MALT） lymphoma. Oxygen radicals induced by Hp can lead to injury of gastric mucosa epithelia and formation of ulcer. In addition, oxygen radicals result in imbalance of proliferation and apoptosis of gastric mucosa epithelia, damage of biomacromolecule such as lipid, protein and DNA and therefore gastric cancer.
出处
《国际消化病杂志》
CAS
2007年第3期191-193,共3页
International Journal of Digestive Diseases
关键词
自由基
幽门螺杆菌
凋亡
抗氧化酶
Oxygen radicals
Helicobacter pylori, Apoptosis
Antioxidants
