过氧化物酶体增殖物激活受体γ、TZD与非酒精性脂肪性肝病

The relation of peroxisome proliferators activated receptor γ、thiazolidinediones and nonalcoholic fatty liver disease

过氧化物酶体增殖物激活受体γ(PPARγ)作为一种核转录因子,能与其特异性配体结合,进而在转录水平上调控多种基因表达,参与脂肪细胞分化、糖脂代谢、动脉硬化、炎症与免疫、肿瘤分化、诱导细胞凋亡等多种生理性效应。PPARγ的合成配体噻唑烷二酮类(TZD)通过改善胰岛素抵抗,有抑制巨噬细胞浸润,抑制炎症介质和血管活性物质合成,抑制肝星状细胞激活、增殖以及减少细胞外基质蓄积等作用,已证实TZD在非酒精性脂肪性肝病的防治中发挥重要作用。

Peroxisome proliferator-activated receptors γ （PPARγ） is ligand activated transcription factors that belong to the nuclear hormone receptor superfamily. The activation of PPARγ can either increase or decrease the transcription of target genes. The genes controlled by PPARγ have been shown to encode proteins or peptides that participate in the pathogenesis of insulin resistance, lipid metabolism, angiosclerosis, inflammation and immunization, differentiation and apoptosis of tumour. Evidently, activation of the nuclear receptor, PPART, by thiazolidinediones has been reported to play an important role in nonalcoholic fatty liver disease（ NAFLD） by ameliorate insulin resistance, suppress macrophage infiltrating, inhibit the activation of hepatic stellate cell and anti-inflammatory actions and so on.