磁共振成像对实验性脊髓空洞症演变动态观察的有用性评价

Value of serial MRI observing development of experimental syringomyelia in rabbits

目的 探讨MRI对实验性脊髓空洞症动态观察和组织学结果的一致性，为MRI能够动态反映SM演变提供依据。方法 取新西兰白兔32只，其中Kaolin组（16只），经皮枕大池穿刺注入高岭土（Kaolin），生理盐水组和假手术组（各8只）作对照。术后定期行MRI扫描并与光镜组织学观察结果对比。结果 2周时，MRI发现上颈髓呈现水肿、缺血变化。4-6周，90%的动物形成空洞。空洞随观察时间延长而增大，累及节段增多。组织学和MRI发现一致。结论 MRI结果与组织学发现一致，能够无创、恰当地动态观察实验性脊髓空洞症的演变过程。

Objective To evaluate efficiency of serial MRI on observing development of experimental syringomyelia in rabbits. Methods Thirty-two New Zealand rabbits （Kaolin group 16 rabbits, physiological saline group 8 rabbits and shamedoperation group 8 rabbits） were used in this study. Kaolin solution was injected into the cisterna magna of the first group animals to produce syringomyelia models and the other two were designed as controls. MR imaging was performed at a regular intervel in all rabbits to compared with the findings of light microscopy. Results At 2 weeks after operation, MRI revealed ischemic and edematous changes in upper cervical cord in 11 of the remained 14 rabbits. At 4-6 weeks, （10/11） 90% animals in Kaolin group developed syringomyelia. Syringomyelia enlarged gradually with time and the number of involved segments increased. Histological results coincided with the MRI findings. Conclusion MRI, coincided with light microscopy, can wholly and correctly observe the development of experimental syringomyelia in rabbits.