摘要
目的探讨18F-FDG PET脑显像对癫痫颅内电极放置位置选择的价值。方法52例难治性癫痫患者,其中男28例,女24例,年龄在7~38岁之间,平均22岁。所有患者脑MRI检查结果无异常。头皮EEG检查阴性23例,头皮EEG检查不确定癫痫部位的29例。采用SIEMENS ECAT47 PET扫描仪行18F-FDG PET脑断层显像,在PET指导下经颅内电极定位后行癫痫灶切除。结果52例癫痫18F-FDG PET显像阳性患者中,发作期8例呈18F-FDG摄取增高,发作间期44例呈18F-FDG摄取减低。发作期18F-FDG PET显像所提示的18F-FDG摄取增高部位,颅内电极都可检测到癫痫波。18F-FDG摄取减低44例患者,能记录癫痫波者39例,有效率为88.6%。5例不能检测癫痫波,无效率为11.4%。结论18F-FDG PET显像对癫痫颅内电极放置位置选择具有指导的价值,尤以发作期18F-FDG PET显像明显。
Objective To explore possibility of 18^F-FDG PET imaging in directing intraeranial electrode placement to sites of epileptogenic focus. Methods Fifty-two cases with intractable epilepsy were studied in 18^F-FDG PET, all of them presented with normal MRI. Out of 52, 23 cases were negative and seizure focus in 29 could not be located in scalp electroencephalography (S-EEG). 18^F-FDG PET cerebral imaging was done using SEIMENS ECAT47 scanner before operation. Intracranial electrode placement to sites of epileptogenic focus was chosen according to the results from 18 F-FDG PET imaging, diagnostic accuracy in 18^F-FDG PET imaging was determined according to the results from electrocorticography (ECoG) or intracranial electroencephalography (I-EEG). Results Epileptogenic foci presented with hypermetabolism in 8 cases during ictal state, hypometabolism in 44 interictally in 18 F-FDG PET imaging. According to above results, epileptogenic focus could be found in 8 cases with ictal epilepsy and in 39 cases with interictal epilepsy by EcoG or I-EEG. However, epileptogenic focus could not be located in other 5 cases with interictal epilepsy. Diagnostic accuracy during ictal and interictal was 100 %, 88.6%,respectively. Conclusion 18^F-FDG PET imaging can be used to localize epileptogenic focus and direct intracranial electrode placement for recording ictal onsets according to metabolic change in sites of epileptogenic foci,especially ictally.
出处
《中国医学影像技术》
CSCD
北大核心
2007年第5期774-776,共3页
Chinese Journal of Medical Imaging Technology
关键词
正电子发射断层
氟代脱氧葡萄糖
癫痫
颅内电极
皮层脑电图
Positron emission tomography
Deoxyglucose
Epilepsy
Intracranial electrode
Electrocorticography