抗抑郁药盐酸氟西汀的合成

Synthesis of the antidepressant-fluoxetine hydrochloride

目的:研究盐酸氟西汀的合成工艺。方法:以苯乙酮为起始原料,经Mannich反应、还原、醚化、去甲基、水解、成盐6步合成盐酸氟西汀。结果:合成盐酸氟西汀的总收率为41.9%。改进了中间体3,4和6的合成工艺。结论:该方法原料易得,操作方便,条件温和,收率较高,适于工业化生产。

Objective ： To study the synthesis of fluoxetinehydrochloride. Methods ： Fluoxetinehydrochloride was prepared using 1-phenylethanone as the starting material via six steps, such as Mannich reaction, reduction, esterification, substitution, hydrolysis, and acidification. Results： Fluoxetinehydro- chloride was obtained in 41.9% total yield. The procedure preparing intermediates 3,4 and 6 was improved. Conclusion： The process is convenient for industrial production with high yield, available raw material and easy operation under mild condition.