期刊文献+

不锈钢微针经皮给药的研究 被引量:13

Transdermal drug delivery using stainless steel microneedle array
下载PDF
导出
摘要 目的:将不锈钢微针阵列应用于经皮给药。考察离体大鼠皮肤经不同针形微针预处理相同时间、相同针形微针预处理不同时间后,模型药物鬼臼毒素经大鼠皮肤的透皮能力。方法:微针预处理大鼠皮肤后,用改进的Franz扩散池研究鬼臼毒素对皮肤的透皮速率。高效液相色谱法测定鬼臼毒素的含量。结果:皮肤经微针预处理后进行鬼臼毒素透皮,其透皮速率比未经微针处理时有明显提高。三角形微针、梯形微针、矛形微针对鬼臼毒素的促渗能力依次增强;三者所引起的鬼臼毒素在皮肤中的滞留量有显著差异。同种针形微针预处理皮肤时间越长,鬼臼毒素的透皮速率越大;但微针预处理时间对皮肤中的药物滞留量无显著影响。结论:微针用于药物经皮给药时,微针针形、微针的预处理时间对药物的经皮渗透具有重要影响。 Objective: To investigate the permeability of podophyllotoxin across the isolated rat skin following applying different needle-shapes of the stainless microneedle array as a transdermal delivery system and different skin pretreating time-points. Methods:The in vitro permeation rates of podophyllotoxin were measured using a Franz diffusion cell fitted with the pretreated rat skins by microneedles. Podophyllotoxin was measured by HPLC. Results:The permeation rates of podophyllotoxin across the skin pretreated with microneedles were higher as compared to those of the untreated. The lanciform microneedles resulted in the highest permeation rate and triangular microneedles had the lowest one. The amount of drug accumulated in the pretreated rat skins was significantly different after applying the different needle-shapes of microneedles. When skins were pretreated using microneedles with the same needle-shape for various time-points, the drug permeation rates were increased with the increase of time. However, the increase of pretreating time had no significant influence on the accumulated amount of drug in skin. Conclusion:The needle-shape and skin pretreating time of the microneedles play the important roles for the transdermal drug delivery.
出处 《中国新药杂志》 CAS CSCD 北大核心 2007年第11期877-880,共4页 Chinese Journal of New Drugs
关键词 微针 经皮给药 鬼臼毒素 microneedles transdermal drug delivery podophyllotoxin
  • 相关文献

参考文献13

  • 1BARRY BW.Novel mechanisms and devices to enable successful transdermal drug delivery[J].Eur J Pharm Sci,2001,14(2):101-114.
  • 2TAO SL,DESAI TA.Microfabricated drug delivery systems:from particles to pores[J].Adv Drug Deliv Rev,2003,55(3):315-328.
  • 3JOSHI A,RAJE J.Sonicated transdermal drug transport[J].J Controlled Release,2002,83(1):13-22.
  • 4YOGESHVAR K,AARTI N,JAMES G,et al.Iontophoretic drug delivery[J].Adv Drug Deliv Rev,2004,56(5):619-658.
  • 5PRAUSNITZ MR.A practical assessment of transdermal drug delivery by skin electroporation[J].Adv Drug Deliv Rev,1999,35(1):61-76.
  • 6LANGER R.Biomaterials in drug delivery and tissue engineering:one laboratory's experience[J].Accounts Chem Res,2000,33(2):94-101.
  • 7LEE S,KOLLIAS N,MCAULIFFE DJ.et al.Topical drug delivery in humans with a single photomechanical wave[J].Pharm Res,1999,16(11):1717-1721.
  • 8PRAUSNITZ MR.Microneedles for transdermal drug delivery[J].Adv Drug Deliv Rev,2004,56(5):581-587.
  • 9MARTANTO W,DAVIS S,HOLIDAY N.et al.Transdermal delivery of insulin using microneedles in vivo[J].Pharm Res,2004,21(6):947-952.
  • 10LIN W,CORMIER M,SAMIEE A,et al.Transdermal delivery of antisense oligonucleotides with microprojection patch(Macroflux)technology[J].Pharm Res,2001,18(12):1789-1793.

同被引文献209

引证文献13

二级引证文献131

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部