艾司佐匹克隆对健康受试者血压的影响

The influence of eszopiclone treatment on blood pressure in healthy volunteers

目的:分析单次口服艾司佐匹克隆对健康受试者血压的影响。方法:选择18～45岁之间的健康受试者26例,随机分为1.8,3.75,7.5,11.25和15.0 mg共5个剂量组。对服药后1,4,8 h的血压进行监测和24 h,7 d随访。结果:受试者的血压在服药后呈下降趋势,服药后各时间点的血压与服药前比较差异均有显著性统计学差异(P<0.05);最大下降幅度为25 mmHg。血压降低较明显者主要集中在服药后1～4 h。11例(42.3%)受试者出现收缩压或舒张压下降>20%的情况,11.25～15 mg剂量组发生率为58.3%(7/12),高于较低剂量组的发生率(28.6%,4/14)。在11.25～15 mg剂量组,有3例血压降低>20%的受试者出现了“头晕”的不良反应。结论:应关注艾司佐匹克隆对血压的潜在影响。

Objective：To analyze the effect of single dose eszopiclone treatment on blood pressure in healthy volunteers. Methods：Twenty-six subjects were involved in the study. They were randomized into 5 subgroups with eszopiclone dosage 1.8 mg, 3.75 mg, 7.5 mg, 11.25 mg and 15.0 mg. The blood pressures were measured at 1 h,4 h, 8 h,24 h and 7 d after eszopiclone treatment. Results：The blood pressures were decreased statistically significantly （ P 〈 0.05 ）. It happened at 1 h and 4 h after treatment. There were 11 subjects （42.3 % ） whose decreased rate of systolic or diastolic blood pressure were up to 20%, and the incidence in 11.25 mg - 15.0mg subgroup （58.3% ,7/12） were higher than that of in the low-dose subgroup （ 28. 6% ,4/14）. Three of these subjects in 11.25 mg ～ 15.0 mg had the adverse reaction of dizziness. Conclusion ： More attention should be paid to the possible effects of eszopiclone on blood pressure.