期刊文献+

原子转移自由基聚合法制备聚乳酸三嵌段共聚物的研究 被引量:3

Synthesis of polylactide block copolymer by atom transfer radical polymerization
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摘要 以自制的双端羟基聚乳酸与α-溴代丙酰溴反应而制得的含溴端基的聚乳酸为大分子引发剂,溴化亚铜/2,2′-联吡啶为催化体系,研究了N-乙烯基吡咯烷酮的原子转移自由基聚合行为,制得了具有两亲性聚乳酸嵌段共聚物。随单体/引发剂摩尔比的增大、聚合温度的升高,共聚物溶液的特性黏度增大,共聚物薄膜的吸水率增加;共聚物在不同降解介质中的降解规律相似,均随降解时间的延长,共聚物薄膜的失重增加,且在不同介质中呈现的降解速率表现为碱液>酸液>水>缓冲液。对聚合物进行了结构表征。 An amphiphilic block copolymer of poly(N-vinylpyrrolidone) and polylactide was synthesized by the atom transfer radical polymerization (ATRP) using N-vinylpyrrolidone as the monomer and polylactide containing α-bromoester group as the macromolecular initiator with CuBr/2, 2'-bipyridine as the catalyst system. The viscosity and the water uptake of polylactide copolymer increased with raising reaction temperature and increasing mole ratio of monomer to macromolecular initiator. Their degradation behaviors in phosphate buffer solution (pH 7.4), water, NaOH or HCl solution at 37℃ were investigated in detail by monitoring the changes in mass during the degradation. The target copolymers degraded rapidly; and the higher of PVP content, the faster the copolymer degraded; degradation of copolymer in NaOH solution was more rapid than others. The characterization of the copolymer was also made.
出处 《现代化工》 EI CAS CSCD 北大核心 2007年第6期35-38,共4页 Modern Chemical Industry
关键词 两亲共聚物 原子转移自由基聚合 聚乳酸大分子引发剂 N-乙烯基吡咯烷酮 amphiphilic copolymer atom transfer radical polymerization polylactide macromolecular initiator Nvinylpyrrolidone
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参考文献14

  • 1Kricheldorf H R. Syntheses and application of polylactides[ J ]. Chemosphere,2001,43(1) :49 - 54.
  • 2Kricheldorf H R, Kreiser-Saunders I. Polylactides: Synthesis, characterization and medical application[ J ]. Macromol Symp, 1996, 103:85 - 102.
  • 3Shi Shuxian,Xia Yuzheng, Ma Xiaoyan, et al. Synthesis and properties of biodegradable ABA triblock copolymers of polylactide (A) and polyethylene glycol (B) [ J ]. Advanced Materials Research, 2006, 11 / 12: 469 - 472.
  • 4陈红丽,贝建中,王身国.生物降解高分子——聚己内酯/聚氧乙烯/聚丙交酯三元共聚物水解行为的研究[J].高分子学报,2000,10(5):626-631. 被引量:26
  • 5Helder J, Dijkstra J, Feijen J. In vitro degradation of glycine/DL-lactic acid copolymers[J]. J Biomed Mater Res, 1990,24(8) : 1005 - 1020.
  • 6Cai Qing, Bei Jianzhong, Wang Shenguo. Synthesis and properties of ABA-type triblock copolymers of poly(glycolide-co-caprolactone) (A) and poly( ethylene glycol) ( B ) [ J ]. Polymer,2002,43 : 3585 - 3591.
  • 7Jin S, Gonsalves K E. Synthesis of poly(1-lactide-eo-serine) and its graft copolymers with poly( ethylene glycol) [ J ]. Polymer, 1998, 39:5155 - 5162.
  • 8Kim J H, Lee S Y, Chung D J. Synthesis and properties of triblock copolymers from L-lacfide and trimethylene carbonate [ J ]. Polymer, 2000,32(12) : 1056 - 1059.
  • 9Nuttelman C R, Henry S M, Anseth K S. Synthesis and characterization of photcrosslinkable, degradable poly( vinyl alcohol)-based tissue engineering scaffolds[ J ]. Biomaterials, 2002,23 : 3617 - 3626.
  • 10Zhu K J, Song B H, Yang S L. Super Microcapsules(SMC) :Ⅰ. Preparation and characterization of star polyethylene oxide(PEO)-pelylactide (PLA) copelymers[ J]. J Polym Sci: Part A. Polym Chin, 1989, 27 (7) :2151 - 2159.

二级参考文献17

  • 1吴素坤,赵炯心.聚乳酸直接缩聚反应的研究[J].国际纺织导报,2001,29(4):30-33. 被引量:13
  • 2王身国,邱波,高家武,段跃新.聚己内酯-聚乙二醇嵌段共聚物Ⅱ.组成、结晶性同降解性间关系[J].高分子学报,1995,5(5):560-565. 被引量:15
  • 3严瑞Xuan.水溶性高分子[M].北京:化学工业出版社,1998..
  • 4[2]Tsuji H.Properties and morphologies of poly(L-lactide):1 Anealing condition effects on properties and morphologiesof poly(L-lactide)[J].Polymer.1994,36(14):2709-2716.
  • 5[6]Fukuzaki H,Yoshida M,Asano M,et al.Synthesis of low-molecular-weight copoly(L-lactic acid/ε-caprolactone)by direct copolycondensation in the absence of catalysts,and enzymatic degradation of the polymers[J].Polymer.1990,31(10):2006-2014.
  • 6[7]Hiltunen K,Jukka V S,Mika H.Lactic acid based poly(ester-urethanes):use of hydroxyl terminated prepolymerin urethane synthesis[J].Journal of AppliedPolymer Science.1997,63:1091-1100.
  • 7[8]Hiltunen K,Jukka V S,Mika H.Lactic acid based poly(ester-urethanes):the effects of different polymerizationconditions on the polymer structure and properties[J].Journal of Applied Polymer Science.1997,64:865-873.
  • 8[9]Hiltunen K,Jukka V S,Mika H.The synthesis of lactic-acid-based telechelic prepolymers[J].Journal of AppliedPolymer Science.1998,67:1011-1016.
  • 9Wang,United States Patent,1999年,5期,952,433页
  • 10严瑞,水溶性高分子,1998年,586页

共引文献49

同被引文献26

  • 1姚军燕,杨青芳,马强.生物高分子材料聚乳酸的改性研究进展[J].高分子材料科学与工程,2004,20(4):28-32. 被引量:44
  • 2周桢,张勇,周正发,袁茂全.端羟基乳酸预聚物的合成[J].塑料,2004,33(5):87-90. 被引量:9
  • 3石淑先,刘健,夏宇正,焦书科,李效玉.原子转移自由基聚合制备两亲性聚乳酸嵌段共聚物(英文)[J].合成橡胶工业,2005,28(6):470-470. 被引量:2
  • 4Kricheldorf H R.Syntheses and application of polylactides[J].Chemosphere,2001,43(1):49-54.
  • 5Kricheldorf H R,Kreiser-Saunders I.Polylactides-synthesis,characterization and medical application[J].Macromol Symp,1996,103:85-102.
  • 6Sinha V R,Trehan A.Biodegradable microspheres for protein delivery[J].Journal of Controlled Release,2003,90:261-280.
  • 7McGinity J W,O'Donnell P B.Preparation of microspheres by the solvent evaporation technique[J].Advanced Drug Delivery Reviews,1997,28:25-42.
  • 8Shi Shuxian,Xia Yuzheng,Ma Xiaoyan,et al.Synthesis and properties of biodegradable ABA triblock copolymers of polylactide (A) and polyethylene glycol (B)[J].Advanced Materials Research,2006(11/12):469-472.
  • 9PILLAI O, PANC, HAGNULA R. Polymers in drug delivery[J]. Curr. Opin. Chem. Biol., 2001, 5: 447-451.
  • 10MIDDLETON J C, TIPTON A J, Synthetic biodegradable polymers as orthopedic devices[J].Biomaterials, 2000, 21: 2335-2346.

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