BH3结构域拟似物BH3I-2′在肿瘤坏死因子凋亡诱导配体诱导白血病细胞凋亡中的协同作用
摘要
肿瘤坏死因子凋亡诱导配体（Tumor necrosis factor apoptosis-inducing ligand，TRAIL）是TNF家族的新成员，可高效特异的杀伤体内肿瘤细胞，有很高的临床应用价值。但在某些肿瘤细胞却存在不同程度的耐受，有效的克服细胞耐药性是目前较为棘手的问题。BH3I-2’是新近合成的小分子量细胞透过分子，它具有与BakBH3蛋白相似的功能， 导凋亡的敏感性及其内在机制。
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2007年第6期411-413,共3页
Chinese Journal of Hematology
基金
天津市教育委员会自然科学基金(20040217)
参考文献10
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共引文献10
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1饶佳,张荣艳.TRAIL在白血病中的研究现状及药物干预[J].实用临床医学（江西）,2006,7(2):143-144.
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3郝继辉,俞鸣,贾丽,柳凤亭,李强,郝希山.蛋白酶体抑制剂在TRAIL诱导恶性淋巴瘤细胞凋亡中的协同作用[J].中国肿瘤临床,2007,34(3):129-131. 被引量：1
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7赵天锁,史玉荣,任贺,郝继辉.恶性淋巴瘤细胞对TRAIL诱导凋亡的抵抗及其分子机制[J].中国肿瘤临床,2009,36(3):156-158.
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9赵天锁,史玉荣,任贺,郝继辉.蛋白酶体抑制剂在肿瘤坏死因子相对凋亡诱导配体诱导恶性淋巴瘤细胞凋亡抵抗中的作用及其分子机制[J].白血病．淋巴瘤,2009,18(6):331-334.
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6郝继辉,俞鸣,李强,史玉荣,杨毅,郝希山.线粒体途径在肿瘤坏死因子凋亡诱导配体诱导结肠癌细胞凋亡中的调节作用[J].中华胃肠外科杂志,2006,9(6):519-522.
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