早期断奶应激(EWS)对仔猪影响的研究——对肾上腺和脾脏重量的影响及体内11-OHCS、维生素C和胆固醇含量变化的试验观察

A STUDY ON THE INFLUENCE OF EWS IN PIGLETS ——Experimental observration on the weight of adrenal gland, spleen and the content changes of internal 11-OHCS, vitamin C and cholesterol

检测了ＥＷＳ对仔猪肾上腺和脾脏的影响及体内肾上腺１１－羟皮质类固醇（１１－ＯＨＣＳ）、维生素Ｃ、胆固醇含量的变化情况，结果表明：（１）断奶后１～１０ｄ，肾上腺的相对重量比断奶前增加２５．５２％～６．９７％（Ｐ＜０．０１～Ｐ＞０．０５），脾脏的相对重量比断奶前减少１６．２５％～２３．４６％（Ｐ＜０．０５～Ｐ＜０．０１）。肾上腺组织学检查呈现皮质增殖，但无炎性变化。断奶２０ｄ后，肾上腺和脾脏相对重量已分别为断奶前水平的１００．３１％和９３．５７％．（２）断奶后１～１０ｄ，血浆中１１－ＯＨＣＳ含量比断奶前增加５６．０９％～６９．０９％（Ｐ＜０．０１），肾上腺和肝组织内１１－ＯＨＣＳ分别比断奶前减少２８．４１％～１７．４７％（Ｐ＜０．０１～Ｐ＜０．０５）和１６．５６％～２３．２５（Ｐ＜０．０５～Ｐ＜０．０１）。断奶后２０ｄ，血浆中、肾上腺和肝组织内１１－ＯＨＣＳ含量分别为断奶前水平的１０１．８３％、９７．４８％和９６．２７％．肾上腺组织内和血浆中维生素Ｃ含量分别比断奶前增加４０．６１％～１６．７３％（Ｐ＜０．０１～Ｐ＜０．０５）和１６．０８％～３０．２０％（Ｐ＜０．０５～Ｐ＜０．０１）。断奶后２０ｄ，其水平分别为断?

The test checked up on the influence of EWS on the weight of adrenal gland and spleen, the content changes of internal 11-OHCS, Vitamin C and cholesterol. The results were:(1)1～10 day(s) after weaning, the relative weight of adrenal gland increased by 25.52% to 6.97% (P<0.01～P<0.05) over the weight before weaning, relative weight of spleen decreased by16.25% to 23.46%(P<0.05～P<0.01) than the weight before weaning. In histologic examination, adrenal gland cortex multiplied, but no inflammation was found. The relative weights of adrenal gland and spleen were 100.31% and 93.57% of the levels before weaning.(2)1～10 day(s) after weaning, the content of 11-OHCS in plasma increased by 56.09% to 69.09%(P<0.01) over the level before weaning, while the contents of 11-OHCS in adrenal gland and liver decreased by 28.41% to 17.47%(P<0.01～P<0.05) and 16.56% to 23.25%(P<0.05～P<0.01), respectively, Compared with the levels before weaning. 20 days after weaning, the contents of 11-OHCS in plasma, adrenal gland and liver were 101.83%, 97.48% and 96.27%, respectively. The contents of Vitamin C in adrenal gland and plasma increased by 40.61% to 16.73% (P<0.01～P<0.05) and 16.08% to 30.20%(P<0.05～P<0.01), respectively, over the levels before weaning. 20 days after weaning the levels of them were 101.80% and 103.34% of the levels before weaning, respectively. The content of cholesterol in plasma decreased by 11.75% to 47.34%(P<0.05～P<0.01), 20 days after weaning the level of it was 98.57% of the level before weaning.