病毒性肝炎及脂肪肝患者血清瘦素的测定

Detection of Serum Leptin Levels in Patients with Viral Hepatitis and Fatty Liver

研究病毒性肝炎患者血清瘦素(leptin)水平的改变,了解瘦素在病毒性肝炎的发病机制中所起的作用。选择诊断明确的病毒性肝炎患者167例,脂肪肝患者87例,对照组80例,检测其血清瘦素水平及各种生化指标,比较各组之间的瘦素水平以及瘦素与各生化指标之间的相关性。结果显示,病毒性肝炎患者血清瘦素水平较脂肪肝患者及对照组均高(P<0.05);女性脂肪肝患者血清瘦素水平较对照组高(P<0.05);而男性脂肪肝患者血清瘦素水平与对照组比较差异无统计学意义(P=0.7811);乙型肝炎和丙型肝炎患者血清瘦素水平较对照组均明显增高(P<0.05);血清瘦素水平与谷丙转氨酶(ALT)、谷草转氨酶(AST)呈显著性正相关(P<0.05);而与血糖(Glu)、总胆固醇(TC)无明显相关性(P>0.05)。结论:病毒性肝炎患者血清瘦素水平升高且与肝脏炎症病变严重程度有关,瘦素可以作为一个判断肝脏炎症严重程度的指标。

In order to find out the correlations between serum leptin levels and viral hepatitis, the serum leptin levels in 167 patients with viral chronic hepatitis, 87 patients with fatty liver, and 80 control subjects were determined by radioimmunoassay. The liver function （ALT, AST）, glucose（Glu） and total cholesterol（TC） in these patients were also measured. Compared with controls and patients with fatty liver, the levels of serum leptin in patients with viral hepatitis were significantly increased（P〈0.05）. Compared with controls, the levels of serum leptin were highly increased in female patients with fatty liver（P〈0.05）, but not in male（P= 0. 7811）. The serum leptin levels in Hepatitis B and Hepatitis C patients were significantly higher than those in control group （P〈0.05）. The serum leptin levels had remarkable positive correlations with ALT and AST（P〈0.05）, but not with Glu and TC（P〉0.05）. The increase of serum leptin levels in the patients with viral hepatitis was correlated positively with the severity of liver inflammation. Therefore, the leptin can be regarded as an indicator to reflect the severity of liver inflammation.