MIC-1蛋白在直肠癌表达的相关性研究及其临床意义

Expression and Clinical Significance of MIC-1 Genes in Rectal Cancer

探讨在直肠癌中MIC-1蛋白表达与病理特征的相关性。用免疫组化法检测73例直肠癌中MIC-1蛋白的表达,并与临床病理因素相关性分析。结果表明:MIC-1蛋白表达均与直肠癌临床分期显著相关,阳性表达率与临床分期有显著性相关。MIC-1阳性表达可作为评价直肠癌发生、发展的生物学指标。

To investigate the correlations between the expressions of Macrophage inhibitory cyto-kine-1 （MIC-1） gene and clinic pathologic feature in patients with rectal cancers, the expressions of MIC-1 in 73 patients with rectal cancer were assessed by immunohistochemistry method, and their correlations with clinical pathologic factors were statistically analyzed. The resuits showed that the expressions of MIC-1 in rectal cancers had significant correlation with clinical stage. There was a significant linear relationship between levels of the MIC-1 onco-protein and clinical stage in patients with rectal cancer. The expression of MIC-1 may be regarded an objective biological marker for estimating the occurrence and progression of rectal cancer.