血栓调节素-活化蛋白C-内皮细胞蛋白C受体系统抗炎症作用研究进展

Advance of thrombomodulin-activated protein C-endothelial cell protein C receptor system for anti-inflammation

血栓调节素-活化蛋白C-内皮细胞蛋白C受体(TM-APC-EPCR)系统除具有传统的抗血栓、促纤溶特性外,最近的研究认为其还在炎症反应过程中相互协调整合,参与抗炎和抗凋亡作用,防止组织细胞受损,发挥保护作用。目前认为该系统作为炎症反应中的重要调节因素,将成为判断严重炎症疾病预后的指标和炎症治疗进程中的新靶点。

Thrombomodulin （TM）, a cell surface-expressed glycoprotein, is a critical cofaetor for thrombin-mediated activation of protein C （PC）, and further amplified by the endothelial cell protein C receptor（EPCR） Activated protein C （ APC ） is best known for natural anticoagulation and increasing fibrinolytic properties. Therefore, TM-APC-EPCR system was involved in regulation of coagulation, Related evidence has revealed that the components of the system were integrated to maintain homeostasis under hypercoagulable and inflammatory conditions. And recent studies suggested that the system could decrease the release of inflammatory cytokines and play a role in anti-apoptosis function, thus alleviate the injury of tissue in serious inflammation. We suggest that TM-APC-EPCR system serving as an important regulator in inflammation, could become novel therapeutic and diagnostic targets for a wide range of inflammatory diseases.