造血干细胞移植后人疱疹病毒6的感染

Human herpesvirus 6 infection after hematopoietic stem cell transplantation

造血干细胞移植(HSCT)是治愈血液系统恶性疾病的有效手段,移植后病毒感染是导致移植失败和患者致死的主要原因之一。人疱疹病毒6型(HHV-6)是最近发现的一种新型疱疹病毒,在人群中的感染率非常高,初次感染后潜伏在人体内,当患者免疫功能受到抑制时,病毒再激活并导致一系列威胁生命的并发症。本文综述了HHV-6的生物学特征、对造血干细胞移植产生的可能影响及其治疗。

Hematopoietic stem cell transplatnation（HSCT） is an effective method to cure hematological malignancies. Virus infection ＂after transplantation is the main cause of transplantation failure and death of patient. Human herpesvirus 6 （HHV-6） is a recently discovered herpesvirus which infects extensively in crowd. HHV- 6 remains latent in the body after primary infection and reactivates in immunosuppressed patient. Then, it induces a series of complications. This article reviewed the biological character istics of HHV-6, its possible impact on hematopoietic stem cell transplantation and treatment.