摘要
合成了能与Mg2+结合的指示剂5F-APTRA-AM的中间体。本实验采用了2种方案即铁粉还原法(方案一)和催化氢化法(方案二),通过实验可知,方案二得到的产物质量、收率均比方案一优;并对2种方案的合成反应条件、影响因素、5-氟-2-氨基酚中的杂质来源分别进行了讨论。
Two feasible methods, reduction with ion powder( Ⅰ ) and catalytic hydrogenation( Ⅱ ) were studied to synthesize the intermediate (2-Amino-5-fluorophenol) of indicator 5F-APTRA-AM which could combined with Mg^2+. The product quality and yield of scheme ( Ⅱ ) was better than the scheme ( Ⅰ ). The synthesis eon- ditions, influence factors and the impurity genesis of 2-Amino-5-fluorophenol of these two methods were also discussed.
出处
《化工技术与开发》
CAS
2007年第6期16-18,共3页
Technology & Development of Chemical Industry