摘要
目的:观察石菖蒲各提取部分对小鼠大脑内5-羟色胺(5-HT)含量的影响。方法:通过给小鼠灌服石菖蒲不同提取部分,用高效液相色谱-电化学检测法分别测定小鼠大脑内5-HT的含量,研究石菖蒲各提取部分对5-HT含量的影响。结果:小鼠灌服石菖蒲后大脑内5-HT的含量变化如下:石菖蒲挥发油组,石菖蒲水煎液及全方组5-HT的含量均比空白组显著升高(P<0.05,P<0.01,P<0.01)。结论:石菖蒲可显著增加小鼠大脑内5-羟色胺的含量,以此推测石菖蒲很可能通过上调脑内5-HT水平,促进血脑屏障的开放。
Objective：To observe the effect of Acorus tatarinowii Schott on level of 5-hydroxytryptamine （5-HT） in mice＇s brain,Methods：The levels of 5-HT in mice＇s brain were determined after po with different components of Acorus tatarinowii Schott by high performance liquid chromatography with electrochemical detection （HPLC-ECD）, and the Acorus tatarinowii Schott＇s effect on the levels of 5-HT was studied.Results：The level of 5-HT in mice＇s brain after administration of naphtha were increased significantly compared to blank group（P〉05, P〉0.01, P〉0.01）.Condusion：Acorus tatarinowii Schott could increase the content of 5-HT, and it was possible to promote the open of blood-brain barrier.
出处
《中国药物应用与监测》
CAS
2007年第3期15-17,共3页
Chinese Journal of Drug Application and Monitoring
基金
国家自然科学基金资助项目(30472140)
关键词
石菖蒲
5-羟色胺
血脑屏障
Acorus tatarinowii Schott
5-Hydroxytryptamine
Blood-brain barrier
