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文昌鱼RACK1基因在胚胎发育中的表达 被引量:3

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摘要 脊椎动物活化的(蛋白)激酶C受体1(receptor for activated C-kinase1,RACK1)在胚胎发育过程中起着至关重要的作用.克隆了RACK1基因在青岛文昌鱼(Branchiostoma belcheri)中的同源基因AmphiRACK1,对其进行了系统的进化学分析,并研究了该基因在正常胚胎发育过程中和经LiCl处理胚胎发育中的时空表达图式.系统进化学分析结果表明,文昌鱼RACK1位于脊椎动物进化枝的基部.在正常胚胎发育中,AmphiRACK1基因在脑泡、神经管和体节中都有明显的表达.在经LiCl处理的胚胎中,该基因在体节中的分节型表达变模糊,表达下调;在脑泡和神经管中的表达下调甚至消失.此外,在成体文昌鱼的轮器、鳃血管、肝盲囊和肠上皮以及精巢中都检测到AmphiRACK1基因不同程度的表达.
出处 《中国科学(C辑)》 CSCD 北大核心 2007年第3期287-292,共6页 Science in China(Series C)
基金 国家自然科学基金资助项目(批准号:30270693 30570967)
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