三种NSAIDS对活动期强直性脊柱炎患者疼痛的疗效及安全性评价

ESTIMATE OF THE EFFICACY AND SAFETY OF THREE KINDS OF NSAIDS IN EASING THE ACHE OF ACTIVE ANKYLOSING SPONDYLITIS PATIENTS

目的:探讨三种非甾体抗炎药物(NSAIDs)尼美舒利、美洛昔康及塞来昔布对活动期强直性脊柱炎(AS)患者疼痛的疗效及安全性。方法:60例活动期AS患者,服药时间从活动期开始到非活动期停用,随机分为三组,A组(尼美舒利)23例、B组(美洛昔康)21例及C组(塞来昔布)16例。比较治疗前后患者的总体疼痛评分VAS、夜间痛、脊柱痛分级变化,并评价三种NSAIDS的总体止痛疗效及安全性。结果:治疗前后患者的总体疼痛评分VAS、夜间痛、脊柱痛分级变化差异显著(P<0.01),治疗后A、B、C组缓解疼痛的总有效率分别为73.9%、76.2%及87.5%,三组比较无显著差异(P>0.05);三组总不良反应发生率分别为13.0%、23.8%及6.3%,C组低于A及B组,但三组间差异无显著性(P>0.05)。不良反应主要集中在胃肠道,无严重心脑血管不良事件发生。结论:尼美舒利、美洛昔康及塞来昔布对活动期AS患者止痛疗效及安全性相似,均具有疗效好、安全性高、患者耐受性好的特点。

Objective： To evaluate the efficacy and safety of three kinds of nonsteroidal antiinflammatory drugs （NSAIDs） in sufferers of active ankylosing spondylitis （AS）. Methods： 60 cases of active AS sufferers, who have been dosed from active time to rest time, were divided into three groups in random,23 cases in A group （ nimesulide）, 21cases in B group （meloxicam） and 16 cases in C group （celecoxib）. The changes of total ache evaluate （ visual analogue scale, VAS）, grades of night ache and spine ache were observed, and the total acesodyne efficacy and safety were evaluated. Results： The total ache VAS, grades of night ache and spine ache were improved significantly after treatment（P 〈0.01 ）. The total ef- fective ratio of easing ache was 73.9% , 76.2% and 87.5% respectively, with no significant differences （P〉0.05）. The rate of side effects was 13.0%, 23.8% and 6.3% respectively, with no significant differences（P 〉0.05）. The side effects mainly focused on stomach and intestines, with no severe side effects. Conclusion ： Nimesulide, meloxicam and celecoxib were similar to active AS patients in the efficacy and safety, and all possessed superior effects, high security and good tolerance.