1CHERVONSKY A V,MEDZHITOV R M,DENZIN L K,et al.Subtle conformational changes induced in major histocompatibility complex class Ⅱ molecules by binding peptides[J].Proc Natl Acad Sci U S A,1998,95:10094-10099.
2MEDZHITOV R,PRESTON-HURLBURT P,JANEWAY C A Jr.A human homologue of the Drosophila Toll protein signals activation of adaptive immunity[J].Nature,1997,388:394-397.
4KAWASAKI K,AKASHI S,SHIMAZU R,et al.Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol[J].J Biol Chem,2000,275:2251-2254.
5ASEA A,REHLI M,KABINGU E,et al.Novel signal transduction pathway utilized by extracellular HSP70:role of toll-like receptor (TLR) 2 and TLR4[J].J Biol Chem,2002,277:15028-15034.
6KURT-JONES E A,POPOVA L,KWINN L,et al.Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus[J].Nat Immunol,2000,1:398-401.
7SABROE I,READ R C,WHYTE M K,et al.Toll-like receptors in health and disease:complex questions remain[J].J Immunol,2003,171:1630-1635.
8MUZIO M,BOSISIO D,POLENTARUTTI N,et al.Differential expression and regulation of toll-like receptors (TLR) in human leukocytes:selective expression of TLR3 in dendritic cells[J].J Immunol,2000,164:5998-6004.
9VIVES P M,SOMOZA N,FERNANDEZ-ALVAREZ J,et al.Evidence of expression of endotoxin receptors CD14,Toll-like receptors TLR4 and LR2 and associated molecule MD-2and of sensitivity to endotoxin(LPS) in islet beta cells[J].J Clin Exp Immunol,2003,133:208-218.
10HYAKUSHIMA N,MITSUZAWA H,NISHITANI C,et al.Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling[J].J Immunol,2004,173:6949-6954.
7OYAMAJ. BLAIS CJR. LIU X. et al. Reduced myocardial ischemia reperfusion injury in toll-like receptor 4-deficient mice[J]. Circulation. 2004. 109 (6) : 784-789.
8CHONG AJ. SHIMAMOTO A. HAMPTON CR. et al. Tolllike receptor 4 mediates ischemia/reperfusion injury of the heartlJ}.J Thorac Cardiovasc Surg , 2004, 128(2) :170-179.
9MAULIK N, ENGELMAN RM, ROUSOUJA, et at. Ischemic preconditioning reduces apoptosis by upregulating anti-death gene Bcl-2[J]. Circulation, 1999, 100(19 suppl) :1369-1375.
10ZHANG D, ZHANG G, HAYDEN MS, et at. A toll-like receptor that prevents infection by uropathogenic bacteria[J]. Science, 2004, 303(5663): 1522-1526.