起搏胶囊治疗家兔病态窦房结综合征的实验研究

Effects of Qibo capsule on rabbits of sick sinus syndrome

目的:观察起搏胶囊对病态窦房结综合征(SSS)家兔的心率、心电图、电生理影响。方法:采用随机、平行对照的研究方法,选用30只家兔制备SSS模型,随机分为3组:模型组、起搏胶囊组、心宝丸组,给予相应的药物干预,10d后观察家兔心率、电生理的情况。结果:起搏胶囊组SSS家兔的平均窦性心动周期、窦房传导时间、窦房结恢复时间、校正窦房结恢复时间、心率较模型组均差异有统计学意义(P<0.05或P<0.01),与心宝丸组比较差异无统计学意义(均P>0.05)。结论:起搏胶囊对窦房结功能损伤的恢复有一定作用,对窦房结损伤心肌组织有一定的修复作用。在改善SSS家兔窦房结功能方面是安全有效的。

Objective：To investigate the effect of Qibo capsule on the heart rate, electrocardiogram, electrophysiology, and pathology of rabbits with sick sinus syndrome（SSS）. Method：Thirty rabbits were used to establish SND models and divided into 3 groups randomly.. Model group, Qibo capsule group, Xinbao group. Rabbits in the three group were treated with corresponding medicine and observed heart rate, electrocardiogram, electrophysiology at 10-day after operation. Result：Compared with the model group rabbits, the Qibo capsule group have markedly statistics difference in sinus cardiac cycle （SCL）, sinoatrial conduction time （SACT）, sinus node recov- ery time （SNRT）, corrected sinus node recover time （SNRTc） and HR （P〈0.05）. There was no statistics difference between Qibo group and Xinbao group （P〈0.05）. Conclusion：The Qibo capsule is effectivity and safe to treat SSS for the mechanism that it contributes to recovery sinus function recovery and injured myocardium repair.