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纳他霉素的生物合成基因研究 被引量：2

Biosynthetic Genes of Natamycin
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摘要 纳他霉素是一种多烯大环内酯类抗真菌抗生素,能专一地抑制酵母和霉菌,作为天然的防腐剂用于食品和饲料行业。概述了纳他霉素的化学结构,作用机理以及基因调控方面的研究,包括合成基因,修饰基因和调节基因。并展望了在纳他霉素基因工程研究方面的前景。 Natamycin is a kind of polyene macrolide antifungal antibiotic not only specifically represses yeast and fungi but also plays as a natural antiseptic in food and forage industry. Chemical structure, effect mechanism, and genetic regulation of natamycin, including synthetic genes, modification genes, regulator genes were outlined in this paper.Vista of genetic engineering study on natamycin was also prospected.
作者 尹亮
机构地区 华南师范大学生命科学学院
出处 《微生物学杂志》 CAS CSCD 2007年第3期92-95,共4页 Journal of Microbiology
关键词 纳他霉素 抗真菌抗生素 基因调控 natamycin antifungal antibiotic gene manipulation
分类号 Q939.92 [生物学—微生物学]
  • 相关文献

参考文献11

  • 1贺家亮,张敏,赵胜娟.纳他霉素的研究现状[J].中国食品添加剂,2005,16(3):30-32. 被引量：26
  • 2芦国营,张朝晖,洪伟杰.新型防腐剂纳他霉素的研究进展[J].饲料工业,2005,26(11):28-31. 被引量：5
  • 3陈冠群,季波.纳他霉素的特性及应用[J].中国乳品工业,2002,30(4):26-28. 被引量：40
  • 4张芳,徐学万.几种天然防腐剂及其在食品中的应用[J].食品工业,2001,22(3):30-31. 被引量：15
  • 5邬建国,王敏.纳他霉素的分子生物学研究进展[J].微生物学通报,2003,30(5):120-123. 被引量：30
  • 6Aparicio JF,Fouces R,Mendes MV,et al.A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces Natalensis[J].Chem Biol,2000,7:895-905.
  • 7Marta V.Mendes,Eliseo Recio,Roberto Fouces,et al.Engineered biosynthesis of novel polyenes:a pimaricin derivative produced by targeted gene disruption in Streptomyces Natalensis[J].Chemistry & Biology,2001,8:635-644.
  • 8Aparicio JF,P Caffrey J,J A Gil,et al.Polyene antibiotic biosynthesis gene clusters[J].Appl Microbiol Biotechnol,2003,61:179-188.
  • 9Tagaki,M.,Takada,H.& Imanaka,T.Nucleotide sequence and cloning in Bacillus subtilis of the Bacillus stearothermophilus pleiotropic regulatory gene degT[J].J.Bacteriol,1990,172:411-418.
  • 10Mendes MV,Aparicio JF.Martin JF Complete nucleotide sequence and characterization of pSNA1 from pimaricinproducing Streptomyces Natalensis that replicates by a rolling circle mechanism[J].Plasmid,2000,43:159-165.

二级参考文献62

  • 1李东,杜连祥,路福平,亓珊,陈婕,李颖辉.纳他霉素的抑菌谱及最小抑菌浓度[J].食品工业科技,2004,25(7):143-144. 被引量：62
  • 2鲍锴,胡志浩,周秀芬,周启,邓子新.一个可在大肠杆菌和链霉菌之间进行属间接合转移的柯斯质粒[J].科学通报,1995,40(15):1440-1440. 被引量：4
  • 3内田佳子,朱安国.游霉素滴耳液对犬真菌性外耳炎的治疗效果[J].牧业译丛,1996(1):14-16. 被引量：3
  • 4朱钦龙.游霉素滴耳液治疗犬真菌性外耳炎的效果[J].养犬,1996,7(2):7-8. 被引量：2
  • 5Enshasy H A, Farid M A. Influence of inoculum type and cultivation conditions on natamycin production by strtomyces natalensis [ J ].J Basic Microbial,2000,5:333.
  • 6Chater K F, Breton C J. Resistance, regulatory and production genes for the antibiotic methlenomy are clustered [J]. EMBO. J, 1985,4:1893.
  • 7Harry Brik. Natamycin[J]. Analytical Profiles of Drug Substances,1994,10:514.
  • 8Hu H, Ochi K. Novel approach for improving the productivity of antibiotic-producing strains by inducing combined resistant mutations[J]. Apland Envi Micro,2001,67:1885.
  • 9Shima J, Hesketh A, Okamoto S, et al. Induction of actinorhodin by rpaL(Eneoding ribosomal protein S12)mutations that confer streptomyein resistance in Streptomyces lividans and streptomyces coelicolor A3(2) [J].J Bacteriol,1996,178:7276.
  • 10Hesketh A, Ochi K. A novel method for in,proving Streptomyces coelieolor A3 (2) for production of actinorhodin by introduction of rpsL(Encoding ribosomal protein S12) mutation conferring resistance to streptmnycin [J]. J Antibiot, 1997,50:532.

共引文献123

同被引文献63

  • 1肖春桥,高洪,池汝安.诱导子促进植物次生代谢产物生产的研究进展[J].天然产物研究与开发,2004,16(5):473-476. 被引量：40
  • 2骆健美,金志华,岑沛霖.培养条件对褐黄孢链霉菌发酵合成纳他霉素的影响[J].浙江大学学报（工学版）,2005,39(2):296-300. 被引量：19
  • 3刘宁,金志华,骆健美,岑沛霖.前体对纳他霉素生物合成的影响[J].中国抗生素杂志,2005,30(6):328-331. 被引量：10
  • 4朱惠,金志华,岑沛霖.纳他霉素产生菌基因组重排育种[J].中国抗生素杂志,2006,31(12):739-742. 被引量：20
  • 5Aparicio J F, Caffrey P, Gil J A, et al. Polyene antibiotic biosynthesis gene clusters[J]. Appl Microbiol Biotechnol, 2003, 61(3): 179-188.
  • 6Welscher Y M, Jones L, Leeuwen M R, et al. Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol[J]. Antimicrob Agents Chemother., 2010, 54(6): 2618-2625.
  • 7Vicente C M, Santos-Aberturas J, Guerra S M, et al. PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis[J]. Microb Cell Fact, 2009, 8(1): 33.
  • 8Aparicio J F, Colina A J, Ceballos E, et al. The biosynthetic gene cluster for the 26-membered ring polyene macrolidepimaricin - A New polyketide synthase organization encoded by two subclusters separated by functionalization genes[J]. J Biol Chem, 1999, 274(15): 10133-10139.
  • 9Aparicio J F, Fouces R, Mendes M V, et al. A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis[J]. Chem Biol, 2000, 7(11): 895-905.
  • 10Krishnan S, Schenkman J B,Rusling J F. Bioelectronic delivery of electrons to cytochrome p450 enzymes[J]. J Phys Chem B, 2011, 115(26): 8371-80.

引证文献2

二级引证文献11

微生物学杂志
2007年 第3期

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