血浆ET和CGRP与高血压左室肥厚的关系研究现状

Investigating Conditions of Plasma Endothelin,Calcitonin Gene-related Peptide and LVH

目的:探讨高血压左室肥厚与血浆ET和CGRP的关系的研究现状。方法:阅读国内外大量相关文献,加以归纳总结,得出结论。结果:血浆ET可能是一种促高血压左室肥厚因子,CGRP可能是一种抗高血压左室肥厚因子。结论:左室肥厚是高血压病人左室重构的重要表现,是发生心、脑血管事件的一个独立危险因素,逆转LVH成为抗高血压治疗的重要目标,通过某种途径使血浆ET浓度下降和CGRP浓度的升高,可能有助于高血压与高血压左室肥厚的治疗。

Objective： To explore the relationship between changes of plasma endothelin （ET）, Calcitonin gene-related peptide （CGRP）levels and left ventricular hypertrophy （LVH）in patients with essential hypertension（EH）. Method： Look up and summarize a great of relevant documents, draw a conclusion. Results： plasma ET may induce EH, plasma CGRP may relieve EH. Conclusions： LVH is risky factor of appearing complication for patients with EH, changing LVH is becoming a significant aim to cure EH, lowering the levels of plasma ET and increasing the levels of CGRP may be benefit to cure EH and LVH.