性病门诊的妊娠合并梅毒患者母婴阻断的临床研究

Clinical study of blocking motherto-child transmission among pregnant women infected with syphilis at STD clinics

目的探讨妊娠合并梅毒患者在妊娠不同孕周进行治疗后,其所生新生儿梅毒阻断率的不同。方法对2001年11月至2005年11月期间,确诊妊娠合并梅毒患者进行回顾性临床分析,并通过对妊娠16周前后的孕妇用苄星青霉素治疗,对其新生儿在出生时和出生后3、6、9、12、18个月检测梅毒抗体,观察疗效。结果16周前、后进行治疗的孕妇所生新生儿阻断率分别为86.1%和76.2%,两者差异有统计学意义(P<0.05)。结论对于妊娠合并梅毒的患者,早期进行青霉素足量治疗可以有效防止胎儿感染梅毒。故妊娠期妇女应该早期常规接受梅毒抗体检测,建议同时检查艾滋病病毒和性病。

Objective To discuss different blocking rates of newborn syphilis in different periods of gestation in pregnant women infected with syphilis after appropriate treatment,Method The outcomes of treatment in two groups of pregnant women were compared,one being treated with benzathine peniciUi for 2 courses in 20 Weeks before pregnancy, and the other being treated for one course in 20 weeks after pregnancy, The newborn babies were tested for syphilis antibody at birth and 3,6,9,12 and 18 months after birth, and the efficacy of treatment was observed. Result The blocking rate in the first group was 86.1% , while that in the second group was 76.2 % . The findings were tested by χ2 statistic analysis, P 〈 0.05 Conclusion For syphilis infected pregnant women,earlier treatment with penicillin.in sufficient doses may effectively prevent syphilis infection of the fetus and so the pregnant women should receive early detection of syphilis antibody and possibly HIV and STD testing.