舌筛状腺癌2例报道及文献复习

Cribriform adenocarcinoma of tongue: A report of two cases and review of literature

目的探讨舌筛状腺癌的临床病理特点和鉴别诊断要点。方法对2例舌筛状腺癌进行临床病理学、免疫组织化学观察和文献复习。结果患者年龄分别为60岁和35岁。肿瘤无包膜,被纤维分隔为小叶,大部分区域表现为实性和微囊状的生长方式。最具有特征性的是肿瘤细胞核淡染、毛玻璃样、常相互重叠。1例术后3年无复发。结论舌筛状腺癌是一种具有独特临床病理特点的新提出的肿瘤,需要与多形性低度恶性腺癌、腺样囊性癌、甲状腺乳头状腺癌鉴别。

Purpose To investigate the clinicopathologic features and differential diagnosis of cribriform adenocarcinoma of the tongue （CAT）. Methods Two cases of CAT were observed by clinicopathologic and immunohistochemical techniques and related literature was reviewed. Results The patients were 60 and 35 years old respectively. The tumors were un - encapsulated and were divided by fibrous septa into lobules. Major parts of the lesions were composed of areas with solid and microcystic growth patterns. The most striking cytological feature was that the tumor cell nuclei were pale staining with a ＂ground glass＂ feature, and they often appeared, to overlap. One case was followed for 3 years and no recurrence was found. Conclusions CAT is a new distinct entity which has unique clinicopathologic features. It should be distinguished from polymorphous low grade adenocarcinoma（ PLGA）, adenoid cystic carcinoma and papillary carcinoma of the thyroid.