DNA双链断裂修复蛋白RAD51在喉癌中的表达及意义

Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance

目的：探讨DNA双链断裂修复蛋白RAD51在喉癌细胞中的表达及其临床意义。方法：应用免疫组织化学SP法检测喉癌和声带息肉组织中RAD51的表达情况，并结合肿瘤的临床TNM分期、淋巴结转移及其病理分化程度等分析它在肿瘤发生发展中的作用。结果：①RAD51在喉癌组中的表达明显强于声带息肉组，差异有统计学意义（P〈0.01）；②RAD51在喉癌组3～4期中的表达强于1～2期喉癌，差异有统计学意义（P〈0．01）；③RAD51在低、中分化喉癌中的表达强于高分化喉癌（P〈0．05），差异有统计学意义；④RAD51在有淋巴结转移喉癌中的表达强于无淋巴结转移喉癌，差异有统计学意义（P〈0.05）。结论：RAD51在喉癌的发生、发展中可能起重要作用，它可能成为临床诊断和治疗喉癌的一个潜在靶点，对预测肿瘤的预后有一定的意义。

Objective：To investigate the expression and clinical significance of RAD51 in laryngocarcinoma, Method：The expression of RAD51 in laryngocarcinoma and polyp of vocal cord tissues were determined by immunohistochemical staining. The results were analyzed and compared with the clinical stage, lymph node metastasis and pathologic grade. Result：①The expression of RAD51 in laryngocarcinoma group was extremely stronger than that in polyp of vocal cord group（ P〈0. 01） .②There was significant difference for RAD51 expression in cancer cells between earlier clinical stage group and advanced clinical stage group（ P 〈0.01）. ③There was significant difference for RAD51 expression in different pathologic grades（ P〈0.05）, OThere was also significant difference for RAD51 expression between groups with and without lymph node metastasis. Conclusion： RAD51 may play a critical role in tumorigenesis of laryngocarcinoma. RAD51 may be a potential marker for clinical diagnosis and treatment of Laryngocarcinoma, It may be significant in predicting clinical stage, pathologic grade and metastasis.