摘要
Objective: To explore the expression of c-Met mRNA in nasopharyngeal carcinomas (NPC) and its relation with clinical biological behavior. Methods: In situ hybridisation was used to detect mRNA expression of c-Met in 15 cases of non-tumor nasopharyngeal (NP), 55 cases of NPC. Results: The positive rates of c-Met mRNA in NP and NPC cells were 13.3% (2/15) and 61.8% (34/55) respectively. The expression of c-Met mRNA was significantly correlated with lymph node metastasis, local invasion (skull base erosion), and clinical stage. In cases with cervical lymph node metastasis, local invasion, and clinical stage III and IV (UICC), the positive rates of expression of c-Met mRNA were significantly higher than that in those without the conditions mentioned above (P < 0.05 or P < 0.01). But it was not significantly correlated with age, gender, histo- logic grade, and cranial nerve palsy (P > 0.05). Conclusion: The abnormal expression of c-Met gene was well correlated with the biological behavior of metastasis and invasion. To detection the expression of c-Met mRNA could serve as an important index to estimate the prognosis of NPC. C-Met may be a new diagnostic/therapeutic target of NPC.
Objective： To explore the expression of c-Met mRNA in nasopharyngeal carcinomas （NPC） and its relation with clinical biological behavior. Methods： In situ hybridisation was used to detect mRNA expression of c-Met in 15 cases of non-tumor nasopharyngeal （NP）, 55 cases of NPC. Results： The positive rates of c-Met mRNA in NP and NPC cells were 13.3% （2/15） and 61.8% （34/55） respectively. The expression of c-Met mRNA was significantly correlated with lymph node metastasis, local invasion （skull base erosion）, and clinical stage. In cases with cervical lymph node metastasis, local invasion, and clinical stage III and IV （UICC）, the positive rates of expression of c-Met mRNA were significantly higher than that in those without the conditions mentioned above （P 〈 0.05 or P 〈 0.01）. But it was not significantly correlated with age, gender, histologic grade, and cranial nerve palsy （P 〉 0.05）. Conclusion： The abnormal expression of c-Met gene was well correlated with the biological behavior of metastasis and invasion. To detection the expression of c-Met mRNA could serve as an important index to estimate the prognosis of NPC. C-Met may be a new diagnostic/therapeutic target of NPC.
关键词
致癌基因
肝生长因子
鼻咽癌
癌细胞转移
hepatocyte growth factor （HGF）
oncogene c-Met
nasopharyngeal carcinoma
invasion
metastasis
