期刊文献+

高血压病患者血清胰岛素样生长因子-1水平的探讨 被引量:1

下载PDF
导出
摘要 目的:探讨高血压病患者血清胰岛素样生长因子-1(IGF-1)的水平变化以及IGF-1与高血压合并左室肥厚(LVH)的关系。方法:采用酶联免疫吸附法测定45例高血压组和52例健康对照组的IGF-1水平。结果:高血压组中IGF-1水平较对照组明显升高;高血压合并LVH组比无合并LVH组IGF-1水平升高。结论:在高血压病患者中,IGF-1水平明显升高,且高血压合并LVH组IGF-1水平明显高于无合并LVH组,提示IGF-1可能参与了高血压及其并发症LVH的发生、发展。
出处 《临床医药实践》 2007年第4期264-265,共2页 Proceeding of Clinical Medicine
  • 相关文献

参考文献5

  • 1EBENSPERGER R,ACEVEDO E,MELENDEZ J,et al.Selective increase in cardiac IGF-1 in a rat model of ventricular hypertrophy[J].Biochem Biophys Res Commun,1998,243(1):20-24.
  • 2朱志军,黄元伟.胰岛素样生长因子1与原发性高血压[J].国外医学(心血管疾病分册),2002,29(2):104-105. 被引量:3
  • 3庞明,梁积英,史文,苏卫红,万里凯,陈晖,胡颖虹,欧华军,赖文.胰岛素样生长因子与高血压关系的研究[J].广西医科大学学报,2002,19(5):641-642. 被引量:3
  • 4HASDAI D,NIELSEN M F,RIZZA R A,et al.Attenuated in vitro coronary arteriolar vasorelaxation to insulin-like growth factor 1 in experimental hypercholesterolemia[J].Hypertension,1999,34 (1):89-95.
  • 5YOANG L H,YIN R F,HU X Y,et al.Insulin-like growth factor 1 stimulates cardiac myosin heavy chain and actin synthesis in the awake rat[J].Am J Physiol,1999,276:143-150.

二级参考文献11

  • 1刘力生.2004年中国高血压防治指南(实用本)[J].中华心血管病杂志,2004,32(12):1060-1064. 被引量:2620
  • 2Ren J, Samson WK, Sowers JR. Insulin-like growth factor I as a cardiac hormone: physiological and pathophysiological implications in heart disease. J Mol Cell Cardiol, 1999; 31(11): 2049~2061
  • 3Re, HER. Amino terminal sequences of two polypeptides from human serum with no-suppresible insulin-like and cellgrowth promoting activities. Proc Natl Acad Sci USA, 1976; 73: 4379~4381
  • 4Jiang X, Srinivasan SR, Dalferes ER Jr, et al. Plasma insulin-like growth factor 1 distribution and its relation to blood pressure in adolescents: the Bogalusa Heart Study. Am J Hypertens, 1997; 10(7 pt 1): 714~719
  • 5Ebensperger R, Acevedo E, Melendez J, et al. Selective increase in cardiac IGF1 in a rat model of ventricular hypertrophy. Biochem Biophys Res Commun, 1998; 243(1): 20~24
  • 6Boger RH, Skamira C, Bode-Boger SM, et al. Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone on patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study. J Clin Invest, 1996; 98(12): 2706~2713
  • 7Leri A, Liu Y, Claudio PP, et al. Insulin-like growth factor1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. Am J Pathol, 1999; 154(2): 567~580
  • 8Hasdai D, Rihal CS. Holmes DR Jr, et al. Insulin and insulin-like growth factor-1 cause coronary vasorelaxation in vitro. Hypertension, 1998; 32(2): 228~234
  • 9耿庆,高尚志.胰岛素样生长因子-I与心血管疾病[J].心血管病学进展,1999,20(6):365-368. 被引量:7
  • 10卜培莉,王淑贞,张运,张梅,黎莉,李传义,郑昭伦,钟明.原发性高血压血清胰岛素样生长因子-1的临床研究[J].中国循环杂志,1999,14(4):196-197. 被引量:10

共引文献3

同被引文献13

引证文献1

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部