A+C群脑膜炎球菌多糖疫苗安全性观察

Safety Investigation on Group A+C Meningococcal Polysaccharide Vaccine

目的客观、系统地评价A+C群脑膜炎球菌多糖疫苗(MPV)使用后的安全性。方法9 992名2～60岁成人和儿童接种疫苗后,通过抽样主动监测和观察对象主动报告,对速发接种反应、全身反应和局部反应进行观察和统计,并对所有接种者跟踪观察1个月以评价长期的不良反应。结果无速发接种反应发生。在主动监测的人群中,14人有中、强发热反应,发生率1.18%;6人有局部强反应,中、强反应发生率0.51%。在主动报告的人群中,8人有中、强发热反应,发生率0.09%。未观察到与疫苗接种相关的任何长期不良反应。结论此次对A+C群MPV使用安全性现场观察,总体接种反应轻微,且发热、红晕等反应均在72h内自行消失,A+C群MPV使用后有良好的安全性。

Objective To evaluated safety of Meningocacol A＋C polysacchride vaccine after immunization. Methods 9 992 volunteers aged 2-60 years old were vaccinated with Meningocacol A＋C polysacchride vaccine,immediate side effects for all volunteers and 1184 volunteers were observed by doctors,the others were reported to CDC by themselves, if any side effect appears, long-term side effect was also investigated, all data were collected and analyzed. Results One immediate side effect was found in all volunteers. In active observation group, 14 volunteers （1.18%） appear ≥37.6℃ fever, 6 volunteers （0.51%） were observed middle grade areola. In volunteers reporting group, 8 volunteers （0. 09%） temperature were ≥37.6℃. Long-term side effect did not found in all volunteers. Conclusion Only few person appear fever and areola that could be recovered in 72 hours, long-term side effect was not found. All data in this experiment showed that the vaccine is safe after vaccination.