血管细胞黏附分子-1和P-选择素对急性冠脉综合征的预测价值

Prediction value of serum VCAM-1 and serum P-selectin in acute coronary syndrome

目的:研究血清血管细胞黏附分子-1和P-选择素水平在急性冠脉综合征中的特点,探讨二者对急性冠脉综合征的预测价值。方法:用酶联免疫吸附法检测29例急性心肌梗死,31例不稳定型心绞痛,30例稳定型心绞痛和30例健康对照者血清sVCAM-1、sP-选择素水平。结果:ACS患者血清sVCAM-1、sP-选择素水平均高于非ACS患者,AMI患者血清sVCAM-1浓度及sP-选择素水平较UA患者升高(均P<0.05)。sVCAM-1、sP-选择素和LDL-C之间呈显著正相关。以x±2s为临界值联合检测sVCAM-1和sP-选择素,对于诊断ACS的灵敏度为72.8%,特异度为83.1%。结论:ACS患者血清VCAM-1、P-选择素水平升高,提示与ACS的发生有关,是动脉粥样硬化斑块不稳定的标志,可以作为ACS的预测指标。

Objective：To investigate the difference and relationships of serum vascular cell adhesion molecule-1 （VCAM- 1） and P-selectin levels in different type of coronary heart diseases and explore the potential predicting factors for the acute coronary syndrome （ACS）.Methods：The levels of serum sVCAM-1 and sP-selectin in 29 acute myocardial infarction （AMI）,31 unstable angina （UA）,30 stable angina （SA） and 30 normal healthy control subjects were measured by ELISA method,comparing the values of sVCAM-1 and sP-selectin among different.Results：Serum sVCAM-1 and sP-selectin lev- els were significantly higher in the ACS group compared with SA group and control group. There was moderate correlative relationship between sVCAM-1 ,sP-selectin and LDL-C. For ACS,the sensitivity was 72.8%, specificity was 83.1%with serum sVCAM-1 and sP-selectin levels.Conclusion：The elevated VCAM-1 and P-selectin levels suggested an obvious relationship with pathogenesis of ACS,which may be a potential markers of plaque instability and may be newly sensitive markers for identifying patients with ACS.