慢性日本血吸虫病患者肝功能异常因素分析

Analysis of factors on abnormal liver function in chronic schistosomiasis japonica patients

目的分析慢性日本血吸虫病(慢血)患者肝功能异常的相关因素以其指导护肝和抗血吸虫治疗。方法收集120例慢血住院患者的临床资料,采用logistic回归法分析肝功能异常的相关因素,总结其护肝治疗方法。结果慢血伴肝功能异常的相关因素依次是乙型肝炎、血脂升高、饮酒、非酒精性脂肪肝、肥胖;其所致的转氨酶升高均可通过常规护肝治疗使肝功能恢复正常并顺利完成吡喹酮抗血吸虫治疗。结论在无器官功能严重损害的情况下,慢血伴肝功能异常经护肝治疗后不影响抗血吸虫的治疗。

Objective To analyze the associated factors on abnormal liver function （LF） in chronic schistosomiaisis japonica patients. Methods The clinical data of 120 inpationts with chronic schistosomiasis were collected and analyzed by logistic regression. The relevant treatment methods were summarized. Results The associated factors on abnormal LF of the patients were hepatitis B, alcohol drinking, hyperlipidemia, nonalcoholic fatty liver disease （NAFLD）, and obesity, respectively. The ordinary medication for improving liver function was effective to these causes. Prazi- quantal can be administrated successfully to these patients after LF normalized. Conclusion Chronic schistosomiasis patients with abnormal LF hut without severe vital organ diseases could be treated with praziquantal after their LF improving.