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CD44分子与乳腺癌

CD44 molecular and breast cancer
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摘要 CD44分子属于黏附分子家族中的一员，其CD44的异常表达与乳腺癌的发生、发展和转移密切相关。近年来研究表明乳腺癌干细胞表面高度表达CD44分子，针对CD44分子与乳腺癌干细胞关系的研究，将为乳腺癌的临床治疗提供新的靶点。 CD44 is one member of the adhesion molecular family. Recent researches suggest that abnormal expression of CD44 in breast cancer is closely related to cancer genesis,progress and metastasis, and CD44 is highly expressed in breast cancer stem cells surfaces. Studies on the relationship between CD44 and breast cancer stem cells will help us find a new therapy target of breast cancer.
作者 许立生（综述） 王水（审校）
机构地区 南京医科大学第一附属医院普通外科甲乳病区
出处 《国际肿瘤学杂志》 CAS 2007年第6期446-448,共3页 Journal of International Oncology
关键词 CD44 乳腺肿瘤 转移 CD44 Breast Neoplasms Metastasis
分类号 R737.9 [医药卫生—肿瘤]
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参考文献18

  • 1Gotte M, Yip GW. Heparanase, hyaluronan, and CD44 in cancers:a breast carcinoma perspective. Cancer Res, 2006, 66 (21) : 10233- 10237.
  • 2Matsumura Y, Tarin D. Significance of CD44 gene products for cancer diagnosis and disease evaluation, Lancet, 1992, 340 ( 8827 ) : 1053- 1058.
  • 3Ioachim E, Charchanti A, Briasoulis E, et al. Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type Ⅳ and laminin in breast cancer: their prognostic value and role in tumour invasion and progression. Eur J Cancer, 2002, 38 (18) :2362-2370.
  • 4Abraham BK, Fritz P, McClellan M, et al. Prevalence of CD44^+/ CD24^-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin Cancer Res, 2005, 11 (3) :1154-1159.
  • 5Lopez JI, Camenisch TD, Stevens MV, et al. CD44 attenuates metastatic invasion during breast cancer progression. Cancer Res, 2005, 65 (15) :6755-6763.
  • 6Diaz LK, Zhou X, Wright ET, et al. CD44 expression is associated with increased survival in node-negative invasive breast carcinoma. Clin Cancer Res, 2005, 11(9) :3309-3314.
  • 7Kopp R, Classen S, Wolf H, et al. Predictive relevance of soluble CD44v6 serum levels for the responsiveness to second line hormone-or chemotherapy in patients with metastatic breast cancer. Anticancer Res, 2001, 21(4B) :2995-3000.
  • 8Ladeda V, Aguirre Ghiso JA, Bal de Kier Joffe E. Function and expression of CD44 during spreading, migration, and invasion of murine carcinoma cells. Exp Cell Res, 1998, 242(2) :515-527.
  • 9Gonzalez-Angulo AM, Sahin A, Krishnamurthy S, et al. Biologic markers in axillary node-negative breast cancer:differential expression in invasive ductal carcinoma versus invasive lobular carcinoma. Clin Breast Cancer, 2006, 7(5) :396-400.
  • 10Thanakit V, Sampatanukul P, Ruangvejvorachai P, et al. The association of co-expression of CD44v4/MMP-9 with different nodal status in high-grade breast carcinoma patients. J Med Assoc Thai, 2005, 88 Suppl 4 : S30-35.

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国际肿瘤学杂志
2007年 第6期

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