摘要
2-甲氧雌二醇(2-ME)是雌二醇的一种天然代谢产物,具有包括抗乳腺癌在内的广谱抗肿瘤作用。研究发现,这种抗肿瘤作用主要与其抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡及抑制血管生成有关,而与雌激素受体无关。因此被认为可以用于乳腺癌治疗。2-ME因可口服、不良反应轻、与其他抗癌药物有协同作用而无交叉耐药,具有良好的应用前景。
2-methoxyestradiol is an endogenous metabolite of estradiol. It possesses a surprisingly broad-spectrum treatment effect on various cancers including breast cancer. Studies show that the treatment effect of 2- methoxyestradiol is attributed to the inhibition of cancer cell proliferation,induction of apoptosis, and inhibition of angiogenesis ,but not to the estrogen receptor. Therefore it is believed that 2-methoxyestradiol can be used for breast cancer treatment and also has a promising application because of its oral administration, low adverse effect, and synergism with other anticancer drugs without cross resistance.
出处
《国际肿瘤学杂志》
CAS
2007年第6期455-457,共3页
Journal of International Oncology
关键词
雌二醇
乳腺肿瘤
抗肿瘤药
细胞凋亡
新生血管化
病理性
Estradiol
Breast neoplasms
Antineoplastic agents
Apoptosis
Neovascularization,path-ological