食管癌变分子生物学研究进展

Research progress in molecular biology of carcinogenesis of esophageal cancer

近年来的研究表明，食管癌变过程中存在着p53-p21和p16-cyclinDl-Rb细胞周期调控系统紊乱和Wnt信号传导通路改变；存在端粒酶活性异常增高；存在一些特殊蛋白和因子的改变，如环氧合酶．2（COX-2）、CIaudins、细胞周期素依赖性蛋白激酶1（CDKl）、血管内皮生长因子（VEGF）等；这些改变在食管癌的发生发展中起重要作用，也与食管癌的早期诊断、治疗有密切关系。

Recent researches indicate that during the carcinogenesis course of esophageal cancer there are cell cycle regulating system and cell signal derangement, such as p53-p21and pl6-cyclinD1-Rb systyms and Wnt signal pathway. There are abnormal telomerase activation, some changes of special proteins and factors such as COX-2, Claudins, CDK1, and VEGF, etc. Those changes may play important roles in the carcinogenesis of esophageal cancer and be related to the early diagnosis and therapy of esophageal carcinoma.